| No.128 |
R. Baba, Y. Hori, S. Mizukami, and K. Kikuchi |
| ''Development of a Fluorogenic Probe with a Transesterification Switch for Detection of Histone Deacetylase Activity'' |
J. Am. Chem. Soc., 134, 14310-14313 (2012) (Featured in JACS Spotlights) |
| No.127 |
S. Mizukami, S. Watanabe, Y. Akimoto, and K. Kikuchi |
| ''No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis'' |
| J. Am. Chem. Soc., 134, 1623-1629 (2012) |
| No.126 |
Y. Hori, K. Nakaki, M. Sato, S. Mizukami, and K. Kikuchi |
| ''Development of Protein Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association and No-wash Live-cell Imaging'' |
| Angew. Chem. Int. Ed., 51, 5611-5614 (2012) |
| No.125 |
K. Dhara, Y. Hori, R. Baba, and K. Kikuchi |
| ''Fluorescent Probe for Detection of Histone Deacetylase Activity Based on Aggregation-induced Emission'' |
| Chem. Commun., 48, 11534-11536 (2012) |
| No.124 |
Z. Zeng, S. Mizukami, and K. Kikuchi |
| ''Simple and Real-time Colorimetric Assay for Glycosidases Activity Using Functionalized Gold Nanoparticles and its Application for Inhibitor Screening'' |
| Anal. Chem., 48, 11534-11536 (2012) |
| No.123 |
H. Matsushita, S. Mizukami, Y. Mori, F. Sugihara, M. Shirakawa, Y. Yoshioka, and K. Kikuchi |
| ''19F MRI monitoring of Gene Expression in Living Cells via Cell Surface β-Lactamase Activity'' |
| ChemBioChem, 13, 1579-1583. (2012) |
| No.122 |
S. Okada, S. Mizukami, and K. Kikuchi |
| ''Switchable MRI Contrast Agents Based on Morphological Changes of pH-Responsive Polymers'' |
| Bioorg. Med. Chem., 20, 769-774 (2012) |
| No.121 |
K. K. Sadhu, S. Mizukami, C. R. Lanam, and K. Kikuchi |
| ''A New Approach for Fluorogenic Protein Labeling via Photoinduced Electron Transfer Based BL-tag Protein Labeling Method'' |
| Chem. Asia. J., 7, 272-276 (2012) |
| No.120 |
T. Terai, H. Ito, K. Kikuchi, and T. Nagano |
| ''Salicylic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes'' |
| Chem. Eur. J., 18, 7377-7381 (2012) |
| No.119 |
T. Terai, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano |
| ''A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase(NAT) Activity of Cells'' |
| Chem. Commun., 48, 2234-2236 (2012) |
| No.118 |
T. Kowada, J. Kikuta, A. Kubo, M. Ishii, H. Maeda, S. Mizukami, and K. Kikuchi |
| ''In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts'' |
| J. Am. Chem. Soc., 133, 17772-17776 (2011) |
| No.117 |
S. Mizukami, T. Yamamoto, A. Yoshimura, S. Watanabe, and K. Kikuchi |
| ''Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-based Multicolor Bioimaging'' |
| Angew. Chem. Int. Ed., 50, 8750-8752 (2011) |
| No.116 |
S. Watanabe, S. Mizukami, Y. Akimoto, Y. Hori, and K. Kikuchi |
| ''Intracellular Protein Labeling with Prodrug-Like Probes Based on Mutant β-Lactamase-Tag'' |
| Chem. Eur. J., 17, 8342-8349 (2011) |
| No.115 |
K. K. Sadhu, S. Mizukami, S. Watanabe, and K. Kikuchi |
| ''Sequential Ordering among Multicolor Fluorophores for Protein Labeling Facility Aggregation-Elimination Based β-Lactam Probes'' |
| Mol. BioSyst., 7, 1766-1772 (2011) |
| No.114 |
S. Mizukami, H. Matsushita, R. Takikawa, F. Sugihara, M. Shirakawa, and K. Kikuchi |
| ''19F MRI Detection of β-Galactosidase Activity for Imaging of Gene Expression'' |
| Chem. Sci., 2, 1151-1155 (2011) |
| No.113 |
A. Yoshimura, S. Mizukami, Y. Hori, S. Watanabe, and K. Kikuchi |
| ''Cell Surface Protein Labeling with Luminescent Nanoparticles via Biotinylation Using Mutant β-Lactamase-tag Technology'' |
| ChemBioChem., 12, 1031-1034 (2011) |
| No.112 |
S. Mizukami, M. Hosoda, T. Satake, S. Okada, Y. Hori, T. Furuta, and K. Kikuchi |
| ''Photocontrolled Compound Release System Using Caged Antimicrobial Peptide'' |
| J. Am. Chem. Soc., 132, 9524-9525 (2010)
|
| No.111 |
K. K. Sadhu, S. Mizukami, S Watanabe, and K. Kikuchi |
| ''Turn-on Fluorescent Switch Involving Aggregation and Elimination Processes for β-Lactamase-Tag'' |
| Chem. Commun., 46, 7403-7405 (2010)
|
| No.110 |
S. Watanabe, S. Mizukami, Y. Hori, and K. Kikuchi |
| ''Multicolor Protein Labeling in Living Cells Using Mutant β-Lactamase-Tag Technology'' |
| Bioconjug. Chem. 2010, 21, 2320-2326. |
| No.109 |
S. Okada, S. Mizukami, and K. Kikuchi |
| ''Application of a Stimuli-responsive Polymer to the Development of Novel MRI Probes''
|
| ChemBioChem., 11, 785-787 (2010)
|
| No.108 |
Y. Hori, Y. Egashira, R. Kamiura, and K. Kikuchi |
| ''Noncovalent-interaction-promoted Ligation for Protein Labeling'' |
| ChemBioChem.,11, 646-648 (2010)
|
| No.107 |
Y. Hori, H Ueno, S. Mizukami, and K. Kikuchi |
| ''Photoactive Yellow Protein-Based Protein Labeling System with Turn-On Fluorescence Intensity'' |
| J. Am. Chem. Soc., 131, 16610-16111 (2009) |
| No.106 |
S. Mizukami, S. Watanabe, Y. Hori, and K. Kikuchi |
| ''Covalent Protein Labeling Based on Non-catalytic β-lactamase and a Designed FRET Substrate'' |
| J. Am. Chem. Soc., 131, 5016-5017 (2009) |
| No.105 |
S. Mizukami, R. Takikawa, F. Sugihara, M. Shirakawa, and K. Kikuchi |
| ''Dual Functional Probe to Detect Protease Activity for Fluorescence Measurement and 19F MRI'' |
| Angew. Chem. Int. Ed., 48, 3641-3643 (2009) |
| No.104 |
S. Mizukami, S. Okada, S. Kimura, and K. Kikuchi |
| ''Design and Synthesis of Coumarin-based Zn2+ Probes for Ratiometric Fluorescence Imaging'' |
| Inorg. Chem.,48, 7630-7638 (2009) |
| No.103 |
S. Mizukami, S. Watanabe, and K. Kikuchi |
| ''Development of Ratiometric Fluorescent Probes for Phosphatases Using pKa-Switching Mechanism'' |
| ChemBioChem,10, 1465-1468 (2009) |
| No.102 |
K. Kikuchi, S. Hashimoto, S. Mizukami, and T. Nagano |
| ''Anion Sensor-Based Ratiometric Peptide Probe for Protein Kinase Activity'' |
| Org. Lett.,11, 2732-2735 (2009) |
| No.101 |
S. Yamaguchi, C. Miura, F.T. Celino, T. Agusa, S. Tanabe, K. Kikuchi, and T. Miura |
| ''Zinc is an essential trace element for spermatogenesis'' |
| Proc. Natl. Acad. Sci. U.S.A.106, 10859-10864 (2009) |
| No.100 |
S. Mizukami, K. Tonai, M. Kaneko, and K. Kikuchi |
| ''Lanthanide-Based Protease Activity Sensors for Time-Resolved Fluorescence Measurements'' |
| J. Am. Chem. Soc., 130, 14376-14377 (2008) |
| No.99 |
S. Mizukami, R. Takikawa, F. Sugihara, Y. Hori, H. Tochio, M. Walchli, M. Shirakawa, and K. Kikuchi |
| ''Paramagnetic Relaxation-based 19F MRI Probe to Detect Protease Activity'' |
| J. Am. Chem. Soc.,130, 794-795 (2008)
|
| No.98 |
R. A. Colvin, A. L. Bush, I. Volitakis, C. P. Fontaine, D. Thomas, K. Kikuchi, and W. R. Holmes |
| ''Insights into Zn2+ Homeostasis in Neurons from Experimental and Modeling Studies''
|
| Am. J. Physiol., Cell Physiol., 294, C726-C742 (2008) |
| No.97 |
T. Yogo, Y. Urano, A. Mizushima, H. Sunahara, T. Inoue, K. Hirose, M. Iino, K. Kikuchi, and T. Nagano |
| ''Selective Photoinactivation of Protein Function through Environment- sensitive Switching of Singlet Oxygen Generation by Photosensitizer'' |
| Proc. Natl. Acad. Sci. U.S.A., 105, 28-32 (2008) |
| No.96 |
K. Hanaoka, K. Kikuchi, T. Terai, T. Komatsu, and T. Nagano |
| ''A Gd3+-Based Magnetic Resonance Imaging Contrast Agent Sensitive to beta-Galactosidase Activity Utilizing a Receptor-Induced Magnetization Enhancement (RIME)'' |
| Chem. Eur. J., 18, 987-995 (2008) |
| No.95 |
K. Hanaoaka, K. Kikuchi, S. Kobayashi, and T. Nagano |
| ''A Time-resolved Long-lived Luminescence Imaging Method Employing Luminescent Lanthanide Probes with a New Microscopy System'' |
| J. Am. Chem. Soc., 129, 13502-13509 (2007) |
| No.94 |
M. Kumagai, Y. Imai, T. Nakamura, Y. Yamasaki, M. Sekino, S. Ueno, K. Hanaoka, K. Kikuchi, T. Nagano, E. Kaneko, K. Shimokado, and K. Kataoka |
| ''Iron Hydroxide Nanoparticles Coated with Poly(ethylene glycol)-poly(aspartic acid) BlockCopolymer as Novel Magnetic Resonance Contrast Agents for in Vivo Cancer Imaging'' |
| Coll. Surf. B-Bioint., 56, 174-181 (2007) |
| No.93 |
T. Komatsu, K. Kikuchi, H. Takakusa, K. Hanaoka, T. Ueno, M. Kamiya, Y. Urano, and T. Nagano |
| ''Design and Synthesis of an Enzyme Activity-Based Labeling Molecule with FluorescenceSpectral Change'' |
| J. Am. Chem. Soc., 128, 6938-6946 (2006) |
| No.92 |
T. Terai, K. Kikuchi, S. Iwasawa, T. Kawabe, Y. Hirata, Y. Urano, and T. Nagano |
| ''Modulation of Luminescence Intensity of Lanthanide Complexes by PhotoinducedElectron Transfer and Its Application to a Long-Lived Protease Probe'' |
| J. Am. Chem. Soc., 128, 6938-6946 (2006) |
| No.91 |
G. Crivat, K. Kikuchi, T. Nagano, T. Priel, M. Hershfinkel, I. Sekler, N. Rozenzweig, and Z. Rosenzweig |
| ''Fluorescence-based Zinc Ion Sensor for Zinc Ion Release from Pancreatic Cells''
|
| Anal. Chem., 78, 5799-5804 (2006) |
| No.90 |
A. Minami, N. Sakurada, S. Fuke, K. K. Kikuchi, T. Nagano, N. Oku, and A. Takeda |
| ''Inhibition of Presynaptic Activity by Zinc Released From Mossy Terminals During Tetanic Stimulation'' |
| J. Neurosci. Res., 83, 167-176 (2006) |
| No.89 |
K. Kikuchi, R.B. Hannak, M.J. Guo, A.J. Kirby, and D. Hilvert |
| ''Toward Bifunctional Antibody Catalysis'' |
| Bioorg. Med. Chem., 14, 6189-6196 (2006) |
| No.88 |
S. Mizukami, T. W. Kim, S. Helquist, and E. T. Kool |
| ''Varying DNA Base Pair Size in Sub-Angstrom Increments: Evidence for a Loose, Not Large, Active Site in Low-fidelity Dpo4 Polymerase'' |
| Biochemistry, 45, 2772-2778 (2006) |
| No.87 |
K. Komatsu, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano |
| ''Selective Zinc Sensor Molecules with Various Affinities for Zn2+, Revealing Dynamics and Regional Distribution of Synaptically Released Zn2+ in Hippocampal Slices'' |
J. Am. Chem. Soc., 127, 10197-10204 (2005)
(Selected as one of100 Current Hot Papers in ACS National Chemistry Week 2006) |
| No.86 |
E. Kawabata, K. Kikuchi, Y. Urano, H. Kojima, A. Odani, and T. Nagano |
| ''Design and Synthesis of Zinc-Selective Chelators for Extracellular Applications'' |
| J. Am. Chem. Soc., 127, 818-819 (2005) |
| No.85 |
L.A. van Meeteren, P. Ruurs, E. Christodoulou, J.W. Goding, H. Takakusa, K. Kikuchi, A. Perrakis, T. Nagano, and W.H. Moolenaar |
| ''Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine-1-phosphate''
|
| J. Biol. Chem., 280, 21155-21161 (2005) |
| No.84 |
R.A.Colvin, P. Fontaine, D. Thomas, T. Hirano, T. Nagano, and K. Kikuchi |
| ''Evidence for pH Dependent Zn2+ Influx in K562 Erythroleukemia Cells: Studies Using ZnAF-2F Fluorescence and Zn-65(2+) Uptaker'' |
| Arch. Biochem. Biophys., 442, 222-228 (2005) |
| No.83 |
E. Sasaki, H. Kojima, H. Nishimatsu, Y. Urano, K. Kikuchi, Y. Hirata, and T. Nagano |
| ''Highly Sensitive Near-infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs'' |
| J. Am. Chem. Soc., 127, 3684-3685 (2005) |
| No.82 |
S. Mizukami, H. Houjou, K. Sugaya, H. Tokuhisa, E. Koyama, T. Sasaki, and M. Kanesato |
| ''Fluorescence Color Modulation by Intramolecular and Intermolecular p-p Interactions in a Helical Zinc(II) Complex'' |
| Chem. Mater., 17, 50-56 (2005) |
| No.81 |
K. Hanaoka, K. Kikuchi, H. Kojima, Y. Urano, and T. Nagano |
| ''Development of a Zinc Ion-selective Luminescent Lanthanide Chemosensor for Biological Applications'' |
| J. Am. Chem. Soc., 126, 12470-12476 (2004) |
| No.80 |
T. Yogo, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano |
| ''Modification of Intracellular Ca2+ Dynamics by Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptor Using Membrane-permeant Probes'' |
| Chemistry & Biology, 11, 1053-1058 (2004) |
| No.79 |
Y. Hu, K.N. Houk, K. Kikuchi, K. Hotta, and D. Hilvert |
| ''Nonspecific Medium Effects versus Specific Group Positioning in the Antibody and Albumin Catalysis of the Base-Promoted Ring-Opening Reactions of Benzisoxazoles'' |
| J. Am. Chem. Soc., 126, 8197-8205 (2004) |
| No.78 |
D. Okada, C.C. Yap, H. Kojima, K. Kikuchi, and T. Nagano |
| ''Distinct Glutamate Receptors Govern Differential Levels of Nitric Oxide Production in a Layer-specific Manner in the Rat Cerebellar Cortex'' |
| Neuroscience, 125, 461-472 (2004) |
| No.77 |
Y. Gabe, Y. Urano, K. Kikuchi, H. Kojima, and T. Nagano |
| ''Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore -Rational Design of Potentially Useful Bioimaging Fluorescence Probe'' |
| J. Am. Chem. Soc., 126, 3357-3367 (2004) |
| No.76 |
S. Kenmoku, Y. Urano, K. Kanda, H. Kojima, K. Kikuchi, and T. Nagano |
| ''Rational Design of Novel Photoinduced Electron Transfer Type Fluorescent Probes forSodium Cation'' |
| Tetrahedron, 60, 11067-11073 (2004) |
| No.75 |
T. Ueno, Y. Urano, K. Setsukinai, H. Takakusa, H. Kojima, K. Kikuchi, K. Ohkubo, S. Fukuzumi, and T. Nagano |
| ''Rational Principles for Modulating Fluorescence Properties of Fluorescein'' |
| J. Am. Chem. Soc., 126, 14079-14085 (2004) |
| No.74 |
H. Koutaka, J. Kosuge, N. Fukasaku, T. Hirano, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano |
| ''A Novel Fluorescent Probe for Zinc Ion Based on Boron Dipyrromethene (BODIPY) Chromophore'' |
| Chem. Pharm. Bull., 52, 700-703 (2004) |
| No.73 |
M. Kanesato, S. Mizukami, H. Houjou, H. Tokuhisa, and E. Koyama |
| ''Comparison of the Bond Lengths for the Lanthanide Complexes of Tripodal Heptadentate Ligands'' |
| J. Alloys Compd., 374, 307-310 (2004) |
| No.72 |
M. Morisawa, K. Komatsu, T. Togo, S. Morisawa, K. Kikuchi, and T. Nagano |
| ''Role of Zinc Ion on the Initiation of Sperm Motility in Starfish'' |
| Zoo. Sci., 21, 1284-1284 (2004) |
| No.71 |
K. Hanaoka, K. Kikuchi, H. Kojima, Y. Urano, and T. Nagano |
| ''Selective Detection of Zinc Ions with Novel Luminescent Lanthanide Probess'' |
| Angew. Chem. Int. Ed., 42, 2996-2999 (2003) |
| No.70 |
T. Inoue, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano |
| ''Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes'' |
| Chemistry & Biology, 10, 503-509 (2003) |
| No.69 |
H. Takakusa, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano |
| ''A Novel Design Method of Ratiometric Fluorescent Probes Based on Fluorescence Resonance Energy Transfer Switching by Spectral Overlap Integral'' |
| Chem. Eur. J., 9, 1479-1485 (2003) |
| No.68 |
T. Shoda, K. Kikuchi, H. Kojima, Y. Urano, H. Komatsu, K. Suzuki, and T. Nagano |
| ''Development of Selective, Visible Light-excitable, Fluorescent Magnesium Probes with a Novel Fluorescence Switching Mechanism'' |
| The Analyst, 128, 719-723 (2003) |
| No.67 |
S. Mizukami, H. Houjou, Y. Nagawa, and M. Kanesato |
| ''First Helical Zinc(II) Complex with a Salen Ligand'' |
| Chem. Commun. 2003, 1148-1149 |
| No.66 |
S. Mizukami, H. Houjou, M. Kanesato, and K. Hiratani |
| ''Adjustment of Twist Angles in Pseudo-helical Lanthanide Complexes by the Size of Metal Ions'' |
| Chem. Eur. J., 9, 1521-1528 (2003) |
| No.65 |
S. Mizukami, T. Nagano, Y. Urano, A. Odani, and K. Kikuchi |
| ''A Fluorescent Anion Sensor That Works in Neutral Aqueous Solution for Bioanalytical Application'' |
| J. Am. Chem. Soc., 124, 3920-3925 (2002) |
| No.64 |
T. Hirano, K. Kikuchi, Y. Urano, and T. Nagano |
| ''Improved Fluorescent Probes for Zinc, ZnAFs, Suitable for Biological Applications'' |
| J. Am. Chem. Soc., 124, 6555-6562 (2002) |
| No.63 |
H. Takakusa, K. Kikuchi, Y. Urano, S. Sakamoto, K. Yamaguchi, and T. Nagano |
| ''Design and Synthesis of an Enzyme-Cleavable Sensor Molecule for Phosphodiesterase Activity Based on Fluorescence Resonance Energy Transfer''
|
| J. Am. Chem. Soc., 124, 1653-1657 (2002) |
| No.62 |
S. Maruyama, K. Kikuchi, T. Hirano, Y. Urano, and T. Nagano |
| ''A Novel, Cell-Permeable, Fluorescent Probe for Ratiometric Imaging of Zinc Ion"'' |
| J. Am. Chem. Soc., 124, 10650-10651 (2002) |
| No.61 |
S. Ueno, M. Tsukamoto, T. Hirano, K. Kikuchi, M. K. Yamada, N. Nishiyama, T. Nagano, N.Matsuki, and Y. Ikegaya |
| ''Mossy Fiber Zn2+ Spillover Modulates Heterosynaptic N-methyl-D-aspartate Receptor Activity in Hippocampel CA3 Circuits'' |
| J. Cell Biology, 158, 215-220 (2002) |
| No.60 |
K. Hanaoka, K. Kikuchi, Y. Urano, M. Narazaki, T. Yokawa, S. Sakamoto, K. Yamaguchi, and T. Nagano |
| ''Design and Synthesis of a Novel Magnetic Resonance Imaging Contrast Agent for Selective Sensing of Zinc Ion'' |
| Chemistry & Biology, 9, 1027-1032 (2002) |
| No.59 |
N. Suzuki, H. Kojima, Y. Urano, K. Kikuchi, Y. Hirata, and T. Nagano |
| ''Orthogonality of Calcium Concentration and Ability of 4,5-Diaminofluorescein (DAF-2) to Detect NO'' |
| J. Biol. Chem., 277, 47-49 (2002) |
| No.58 |
W. Nakanishi, K. Kikuchi, T. Inoue, K. Hirose, M. Iino, and T. Nagano |
| ''Hydrophobic Modifications at 1-Phosphate of Inositol 1,4,5-Trisphosphate Analogues Enhance Receptor Binding'' |
| Bioorg. Med. Chem. Lett., 12, 911-913 (2002) |
| No.57 |
Y. Hori and Y. Sugiura |
| ''Conversion of Antennapedia Homeodomain to Zinc Finger-like Domain: Zn(II)-Induced Change in Protein Conformation and DNA Binding'' |
| J. Am. Chem. Soc. 124, 9362-9363 (2002) |
| No.56 |
| T. Inoue, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano |
| ''Small Molecule-based Laser Inactivation of Inositol 1,4,5-Triphosphate Receptor'' |
| Chemistry & Biology, 8, 9-15 (2001) |
| No.55 |
| H. Takakusa, K. Kikuchi, Y. Urano, T. Higuchi, and T. Nagano |
| ''Intramolecular Fluorescence Resonance Energy Transfer System with Coumarin Donor Included in beta-Cyclodextrin'' |
| Anal. Chem., 73, 939-942 (2001) |
| No.54 |
K. Hanaoka, K. Kikuchi, Y. Urano, and T. Nagano |
| ''Selective Sensing of Zinc Ion with A Nobel Magnetic Resonance Imaging Contrast Agent'' |
| J. Chem. Soc., Perk. Trans. 2, 1840-1843 (2001) |
| No.53 |
H. Kojima, M. Hirotani, N. Nakatsubo, K. Kikuchi, Y. Urano, T. Higuchi, Y. Hirata, and T. Nagano |
| ''Bioimaging of Nitric Oxide with Fluorescent Indicators Based on Rhodamine Chromophore'' |
| Anal. Chem., 73, 1967-1973 (2001) |
| No.52 |
H. Kojima, M. Hirata, Y. Kudo, K. Kikuchi, and T. Nagano |
| ''Visualization of Oxygen Concentration-dependent Production of Nitric Oxide in Rat Hippocampal Slices During Aglycemia'' |
| J. Neurochem., 76, 1404-1410 (2001) |
| No.51 |
K. Tanaka, T. Miura, N. Umezawa, Y. Urano, K.Kikuchi, T. Higuchi, and T. Nagano |
| ''Rational Design of Fluorescein-based Fluorescence Probes. -Mechanism-based Design of a Maximum Fluorescence Probe for Singlet Oxygen-'' |
| J. Am. Chem. Soc., 123, 2530-2536 (2001) |
| No.50 |
J.M. Park, T. Higuchi, K. Kikuchi, Y. Urano, H. Hori, T. Nishino, J. Aoki, K. Inoue, and T. Nagano |
| ''Selective Inhibition of Human Inducible Nitric Oxide Synthase by S-Alkyl-L-isothiocitrulline-containing Dipeptides'' |
| Br. J. Pharmacol., 132, 1876-1882 (2001) |
| No.49 |
M. Nagaoka, T. Kaji, M. Imanishi, Y. Hori, W. Nomura, and Y. Sugiura |
| ''Multi-Connection of Identical Zinc Finger: Implication for DNA Binding Affinity and Unit Modulation of Three Zinc Finger Domain'' |
| Biochemistry 40, 2932-2941(2001) |
| No.48 |
| T. Hirano, K. Kikuchi, Y. Urano, T. Higuchi & T. Nagano |
| ''Highly Zinc-selective Fluorescent Sensor Molecules Suitable for Biological Applications'' |
| J. Am. Chem. Soc., 122, 12399-12400 (2000) |
| No.47 |
Y. Kawanishi, K. Kikuchi, H. Takakusa, S. Mizukami, Y. Urano, T. Higuchi & T. Nagano |
| ''Design and Synthesis of Intramolecular Resonance Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution'' |
| Angew. Chem. Int. Ed., 39, 3438-3440 (2000) |
| No.46 |
T. Hirano, K. Kikuchi, Y. Urano, T. Higuchi & T. Nagano |
| ''Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications'' |
| Angew. Chem. Int. Ed., 39, 1052-1054 (2000) |
| No.45 |
M. Koresawa, K. Kikuchi, S. Mizukami, H. Kojima, Y. Urano, T. Higuchi & T. Nagano |
| ''Development of Time-resolved Fluorometric Detection System Using Diffusion-enhanced Energy Transfer'' |
| Anal. Chem., 72, 4904-4907 (2000) |
| No.44 |
K. Hotta, K. Kikuchi & D. Hilvert |
| ''Decarboxylation of 3-Carboxybenzisoxazoles by Hydrophobic Antibody Binding Pockets'' |
| Helv. Chem. Acta, 83, 2183-2191 (2000) |
| No.43 |
F. Hollfelder, A. J. Kirby, D. S. Tawfik, K. Kikuchi & D. Hilvert |
| ''Characterization of Proton-Transfer Catalysis by Serum Albumins'' |
| J. Am. Chem. Soc., 122, 1022-1029 (2000) |
| No.42 |
H. Kojima, M. Hirotani, Y. Urano, K. Kikuchi, T. Higuchi & T. Nagano |
| ''Fluorescent Indicators for Nitric Oxide Based on Rhodamine Chromophore'' |
| Tetrahedron Lett., 41, 69-72 (2000) |
| No.41 |
M. Kakoki, Y. Hirata, H. Hayakawa, E. Suzuki, D. Nagata, A. Tojo, H. Nishimatsu, K. Kikuchi, T. Nagano & M. Omata |
| ''Effects of Tetrahydrobiopterin on Endothelial Dysfunction in Rats with Ischemic Acute Renal Failure'' |
| J. Am. Soc. Nephrol., 11, 301-309 (2000) |
| No.40 |
T. Ohno, N. Suzuki, T. Dokoh, Y. Urano, K. Kikuchi, M. Hirobe, T. Higuchi & T. Nagano |
| ''Remarkable Axial Thiolate Ligand Effects on the Oxidation of Hydrocarbons
by Active Intermediate of Iron Porphyrin and Cytochrome P450'' |
| J. Inorg. Biochem., 82, 123-125 (2000) |
| No.39 |
M. Tamura, Y. Urano, K. Kikuchi, T. Higuchi, M. Hirobe & T. Nagano |
| ''Synthesis and Superoxide Dismutase Activity of Novel Iron Complexes'' |
| J. Organomet. Chem., 611, 586-592 (2000) |
| No.38 |
M. Tamura, Y. Urano, K. Kikuchi, T. Higuchi, M. Hirobe & T. Nagano |
| ''Superoxide Dismutase Activity of Iron(II) TPEN Complex and Its Derivatives'' |
| Chem. Pharm. Bull., 48, 1514-1518 (2000) |
| No.37 |
T. Dokoh, N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi & T. Nagano |
| ''A New Thioether-ligated Iron Porphyrin as a Model of a Protonated Form of P450 Active Site'' |
| J. Inorg. Biochem., 82, 127-132 (2000) |
| No.36 |
K. Setsukinai, Y. Urano, K. Kikuchi, T. Higuchi & T. Nagano |
| ''Fluorescence Switching by O-Dearylation of 7-Aryloxycoumarins.-Development of Novel Fluorescence Probes to Detect Reactive Oxygen Species With High Selectivity'' |
| J. Chem. Soc. Perk. Trans. 2, 2453-2457 (2000) |
| No.35 |
N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi, T. Uchida, M. Mukai, T. Kitagawa & T. Nagano |
| ''First Synthetic NO-heme-thiolate Complex Relevant to Nitric Oxide Synthase and Cytochrome P450nor'' |
| J. Am. Chem. Soc., 122, 12059-12062 (2000) |
| No.34 |
Y. Hori, K. Suzuki, Y. Okuno, M. Nagaoka, S. Futaki, and Y. Sugiura |
| ''Artificial Zinc Finger Peptide Containing a Novel His4 Domain'' |
| J. Am. Chem. Soc. 122, 7648-7653 (2000) |
| No.33 |
M. Imanishi, Y. Hori, M. Nagaoka, and Y. Sugiura |
| ''DNA-Bending Finger: Artificial Design of 6-Zinc Finger Peptides with Polyglycine Linker and Induction of DNA Bending'' |
| Biochemistry 39, 4383-4390(2000) |
| No.32 |
S. Mizukami, K. Kikuchi, T. Higuchi, Y. Urano, T. Mashima, T. Tsuruo & T. Nagano |
| "Imaging of Caspase-3 Activation in HeLa Cells Stimulated with Etoposide Using a Novel Fluorescent Probe"
|
| FEBS Lett., 453, 356-360 (1999) |
| No.31 |
T. Inoue, K. Kikuchi, K. Hirose, M. Iino & T. Nagano |
| "Synthesis and Evaluation of 1-Position-modified Inositol 1,4,5-Trisphosphate Analogs" |
| Bioorg. Med. Chem. Lett., 9, 1697-1702 (1999)
|
| No.30 |
N. Umezawa, K. Tanaka, Y. Urano, K. Kikuchi, T. Higuchi & T. Nagano |
| ''Novel Fluorescent Probes for Singlet Oxygen'' |
| Angew. Chem. Int. Ed., 38, 2899-2901 (1999) |
| No.29 |
H. Kojima, Y. Urano, K. Kikuchi, T. Higuchi & T. Nagano |
| ''Fluorescent Indicators for Imaging Nitric Oxide Production'' |
| Angew. Chem. Int. Ed., 38, 3209-3212 (1999) |
| No.28 |
H, Kojima, N. Nakatsubo, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata & T. Nagano |
| ''Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators'' |
| Anal. Chem., 70, 2446-2453 (1998) |
| No.27 |
M. Kakoki, Y. Hirata, H. Hayakawa, A. Tojo, D. Nagata, E. Suzuki, K. Kimura, A. Goto, K. Kikuchi, T. Nagano & *M. Omata |
| ''Effects of Hypertension, Diabetes Mellitus and Hypercholesterolemia on Endothelin Type B Receptor-mediated Nitric Oxide Release from Rat Kidney'' |
| Circulation, 99, 1242-1248 (1999) |
| No.26 |
H. Hayakawa, Y. Hirata, M. Kakoki, Y. Suzuki, H. Nishimatsu, D. Nagata, E. Suzuki, K. Kikuchi, T. Nagano, K. Kangawa, H. Matsuo, T. Sugimoto & M. Omata |
| ''Role of Nitric Oxide-cGMP Pathway in Adrenomedullin-induced Vasodilation in Rat'' |
| Hypertension, 33, 689-693 (1999) |
| No.25 |
M. Kakoki, Y. Hirata, H. Hayakawa, H. Nishimatsu, Y. Suzuki, D. Nagata, E. Suzuki, K. Kikuchi, T. Nagano & M. Omata |
| ''Effects of Vasodilatory b-Adrenoceptor Antagonists on Endothelium-Derived Nitric Oxide Release in Rat Kidney'' |
| Hypertension, 33, 467-471 (1999) |
| No.24 |
N. Kobayashi, T. Higuchi, Y. Urano, K.Kikuchi, M. Hirobe & T. Nagano |
| ''Dipeptides Containing L-Arginine Analogs: New Isozyme-selective Inhibitors of Nitric Oxide Synthase'' |
| Biol. Pharm. Bull., 22, 936-940 (1999) |
| No.23 |
N. Suzuki, T. Higuchi, Y. Urano, K.Kikuchi, H. Uekusa, Y. Ohashi, T. Uchida, T. Kitagawa & T. Nagano |
| ''Novel Iron Porphyrin-alkanethiolate Complex with Intramolecular NH...S Hydrogen Bond: Synthesis, Spectroscopy and Reactivity'' |
| J. Am. Chem. Soc., 121, 11571-11572 (1999) |
| No.22 |
H. Kojima, N. Nakatsubo, K.Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata & T. Nagano
|
| ''Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators'' |
| Anal. Chem., 70, 2446-2453 (1998) |
| No.21 |
N. Nakatsubo, H. Kojima, K. Kikuchi, H. Nagoshi, Y. Hirata, D. Maeda, Y. Imai, T. Irimura & T. Nagano |
| ''Direct Evidence of Nitric Oxide Production from Bovine Aortic Endothelial Cells Using New Fluorescence Indicators: Diaminofluoresceins'' |
| FEBS Lett., 427, 263-266 (1998) |
| No.20 |
H. Kojima, N. Nakatsubo, K. Kikuchi, Y. Urano, T. Higuchi J. Tanaka, Y. Kudo & T. Nagano |
| ''Direct Evidence of NO Production in Rat Hippocampus and Cortex Using a New Fluorescent Indicator: DAF-2 DA'' |
| Neuroreport, 9, 3345-3348 (1998) |
| No.19 |
H. Kojima, K. Sakurai, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata & T. Nagano |
| ''Development of a Fluorescent Indicator for Bioimaging of Nitric Oxide'' |
| Chem. Pharm. Bull., 46, 373-375 (1998) |
| No.18 |
N. Nakatsubo, H. Kojima, K. Sakurai, K. Kikuchi, H. Nagoshi, Y. Hirata, T. Akaike, H. Maeda, Y. Urano, T. Higuchi & T. Nagano |
| ''Improvement of Nitric Oxide Detection Method Using 2,3-Diaminonaphthalene and Its Application to Evaluation of Novel Nitric Oxide Synthase Inhibitor'' |
| Biol. Phram. Bull., 21, 1247-1250 (1998) |
| No.17 |
H. Nakagawa, T. Higuchi, K. Kikuchi, Y. Urano & T. Nagano |
| ''Selective Deoxygenation of Heteroaromatic N-Oxides with Olefins Catalyzed by Ruthenium Porphyrin'' |
| Chem. Pharm. Bull., 46, 1656-1657 (1998) |
| No.16 |
H. Kurumatani, K. Kikuchi, T. Nagano, M. Hirobe, J. Yamazaki & T. Nagano |
| ''Real Time Measurement of Nitric Oxide Release from Cultured Endothelial Cells'' |
| Biol. Pharm. Bull., 21, 1286-1289 (1998) |
| No.15 |
Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, E. Suzuki, D. Nagata, K. Kimura, A. Goto, K. Kikuchi, T. Nagano, M. Hirobe & M. Omata |
| ''Receptor Subtype for Vasopressin-induced Release of Nitric Oxide from Rat Kidney'' |
| Hypertension, 29, 58-64 (1997) |
| No.14 |
H. Kojima, K. Kikuchi, M. Hirobe & T. Nagano |
| ''Real-time Measurement of Nitric Oxide Production in Rat Brain by the Combination of Luminol-H2O2 Chemiluminescence and Microdialysis'' |
| Neurosci. Lett., 233, 157-159 (1997) |
| No.13 |
H. Kojima, K. Sakurai, K.Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata, T. Akaike, H. Maeda & T. Nagano |
| ''Development of a Fluorescent Indicator for the Bioimaging of Nitric Oxide'' |
| Biol. Pharm. Bull., 20 1229-1232 (1997) |
| No.12 |
K.Kikuchi, S. N. Thorn & D. Hilvert |
| ''Albumin-catalyzed Proton Transfer'' |
| J. Am. Chem. Soc., 118, 8184-8185 (1996) |
| No.11 |
K.Kikuchi & D. Hilvert |
| ''Antibody Catalysis Via Strategic Use of Haptenic Charge'' |
| Acta Chem. Scand., 50, 333-336 (1996) |
| No.10 |
K. Kikuchi, T. Nagano & M. Hirobe |
| ''Nobel Detection Method of Nitric Oxide Using Horseradish Peroxidase'' |
| Biol. Pharm. Bull., 19, 649-651 (1996) |
| No.9 |
Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, K. Kimura, A. Goto, K.Kikuchi, T. Nagano,M. Hirobe & M. Omata |
| ''Nitric Oxide Release from Kidneys of Hypertensive Rats Treated with Imidapril'' |
| Hypertension, 27 Part 2, 672-678 (1996) |
| No.8 |
Y. Hirata, H. Hayakawa, E. Suzuki, K. Kimura, K.Kikuchi, T. Nagano, M. Hirobe & M. Omata |
| “Direct Measurement of Endothelium Derived Nitric Oxide Release by Stimulation of Endothelin Receptors in Rat Kidney and Its Alteration in Salts-inducedHypertension”'' |
| Circulation, 91, 1229-1235 (1995) |
| No.7 |
H. Hayakawa, Y. Hirata, E. Suzuki, M. Kakoki, K.Kikuchi, T. Nagano, M. Hirobe& M. Omata |
| “Endothelium-derived Relaxing Factors in the Kidney of Spontaneously Hypertensive Rats'' |
| Life Sci., 56, 401-408 (1995) |
| No.6 |
H. Hayakawa, Y. Hirata, E. Suzuki, K. Kimura, K.Kikuchi, T. Nagano, M. Hirobe& M. Omata |
| “Long-term Administration of L-Arginine Improves Nitric Oxide Release from Kidney in DOCA Salt Hypertensive Rats'' |
| Hypertension, 23, 752-756 (1994) |
| No.5 |
K.Kikuchi, T. Nagano, H. Hayakawa, Y. Hirata & M. Hirobe |
| “Real Time Measurement of Nitric Oxide Produced Ex Vivo by Luminol-H2O2Chemiluminescence Method'' |
| J. Biol. Chem., 268, 23106-23110 (1993) |
| No.4 |
K.Kikuchi, T. Nagano, H. Hayakawa, Y. Hirata & M. Hirobe |
| “Detection of Nitric Oxide Production from a Perfused Organ by a Luminol-H2O2 Syste'' |
| Anal. Chem., 65, 1794-1799 (1993) |
| No.3 |
H. Hayakawa, Y. Hirata, E. Suzuki, T. Sugimoto, H. Matsuoka, K. Kikuchi, T. Nagano, M. Hirobe & T. Sugimoto |
| “Mechanisms for Altered Endothelium-dependent Vasodilation in Isolated Kidneys from SHR, DOCA-salt Hypertensive Rat and Dahl Salt-sensitive Rats'' |
| Am. J. Physiol., 264, H1535-H1541 (1993) |
| No.2 |
K. Kikuchi, H. Hayakawa, T. Nagano, Y. Hirata, T. Sugimoto & M. Hirobe |
| “New Method of Detecting Nitric Oxide Production'' |
| Chem. Pharm. Bull., 40, 2233-2235 (1992) |
| No.1 |
K.Kikuchi, Y. Nagatsu, Y. Makino, T. Mashino, S. Ohta, & M. Hirobe |
| “Metabolism and Penetration through Blood-brain-barrier of Parkinsonism-related Compounds -1,2,3,4-Tetrahydroisoquinoline and1-Methyl-1,2,3,4-tetrahydroisoquinoline-'' |
| Drug Met. Disp., 19, 257-262 (1991) |
