原著論文

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2019年度 2020年度 2021年度 2022年度 2023年度 2024年度
No.202
著　者 T. Nonomura, M. Minoshima, K. Kikuchi
論文名 'Light-Activated Gene Expression System Using a Caging-Group-Free Photoactivatable Dye'
掲載誌頁 Angew. chem. lnt. Ed, (2024), e202416420
No.201
著　者 Y. Wu, M. Minoshima, K. Kikuchi
論文名 'Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI'
掲載誌頁 Front. Chem., (2024), 12, 1408509
No.200
著　者 T. Kamikawa, A. Hashimoto, N. Yamazaki, J. Adachi, A. Matsushima, K. Kikuchi, Y. Hori
論文名 'Bioisostere-conjugated fluorescent probes for live-cell protein imaging without non-specific organelle accumulation'
掲載誌頁 Chem. Sci., (2024), 15, 8097-8105
No.199
著　者 R. Hashimoto, M. Minoshima, K. Kikuchi
論文名 'Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light-Triggered DNA Recombination'
掲載誌頁 ChemBioChem, (2024), 25, e202300799
No.198
著　者 Y. Konishi, Y. Otera, M. Minoshima, K. Kikuchi
論文名 'Activatable 19F MRI probe for detection of α-amylase activity'
掲載誌頁 Chem. Lett., (2024), 53, upae003
No.197
著　者 K. Torii, S. Benson, Y. Hori, M. Vendrell, K. Kikuchi
論文名 'No-wash fluorogenic labeling of proteins for reversible photoswitching in live cells'
掲載誌頁 Chem. Sci., (2024), 15, 1393
No.196
著　者 T. Ochiai, T. Inukai, M. Akiyama, K. Furui, M. Ohue, N. Matsunori, S. Inuki, M. Uesugi, T. Sunazuka, K. Kikuchi, H. Kakeya, Y. Sakakibara
論文名 'Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity'
掲載誌頁 Commun. Chem., (2023), 6, 249,
No.195
著　者 Y. Konishi, M. Minoshima, K. Fujihara, T. Uchihashi, K. Kikuchi
論文名 'Elastic Polymer Coated Nanoparticles with Fast Clearance for 19F MR Imaging'
掲載誌頁 Angew. chem. lnt. Ed, (2023), e202308565
No.194
著　者 K. Torii, Y. Hori, K. Kikuchi
論文名 'President Fluorescence Switching of a Probe Using a Photo-chromic Quencher with High Photostability Assisted by Protein-Surface Modification'
掲載誌頁 Anal. Chem., (2023), 95, 23, 8834-8841
No.193
著　者 Y. Matsui, T. Kowada, Y. Ding, P. R. Sahoo, K. Kikuchi, S. Mizukami
論文名 'Long-term imaging of intranuclear Mg2+ dynamics during mitosis using a localized fluorescent probe'
掲載誌頁 Chem. commun., (2023), 59, 7048
No.192
著　者 M. Nishiura, Y. Hori, M. Umeno, K. Kikuchi
論文名 'Visualization of multiple localizations of GLUT4 by fluorescent probes of PYP-tag with designed unnatural warhead'
掲載誌頁 Chem. Sci., Advance Article (2023), DOI:10.1039/D3SC00724C
No.191
著　者 M. Minoshima, T. Umeno, K. Kadooka, M. Roux, N. Yamada, *K. Kikuchi
論文名 'Development of a Versatile Protein Labeling Tool for Live-Cell Imaging Using Fluorescent β-Lactamase Inhibitors'
掲載誌頁 Angew. chem. lnt. Ed, 62, e20231704 (2023)
No.190
著　者 S. Yari, *J. Kikuta, H. Shigyo, Y. Miyamoto, D. Okuzaki, Y. Furusawa, M. Minoshima, K. Kikuchi, *M. Ishii
論文名 'JAK Inhibition Ameliorates Bone Destruction by Simultaneously Targeting Mature Osteoclasts and Their Precursors'
掲載誌頁 Inflamm. Regen., 43, 1-12 (2023)
No.189
著　者 *M. M. Tomczyk, M. Minoshima, K. Kikuchi, A. Blacha-Grzechnik, Z. Starosolski, Z. Starosolski, R. Bhavane, M. Zalewski, *N. Kuznik
論文名 'Hybrid, Dual Visible and Near-Infrared Fluorescence Emission of (6, 5) Single-Walled Carbon Nanotubes Modified with Fluorescein through Aryl Diazonium Salt Chemistry'
掲載誌頁 Nanotechnology, 34, 055703 (2023)
No.188
著　者 A. Nakayama, Y. Kumamoto, M. Minoshima, K. Kikuchi, A. Taguchi, K. Fujita
論文名 'Photoinitiator-Free Two-Photon Polymerization of Biocompatible Materials for 3D Micro/Nanofabrication'
掲載誌頁 Advanced Optical Materials, 10, 2200474 (2022)
No.187
著　者 R. Hashimoto, M. Minoshima, S. Sakata, F. Ono, H. Ishii, Y. Watakabe, T. Nemoto, S. Yanaka, K. Kato, K. Kikuchi
論文名 'Efficient Visible/NIR Light-driven Uncaging of Hydroxylated Thiazole Orange-based Caged Compounds in Aqueous Media'
掲載誌頁 Chemical Science, 13, 7462-7467 (2022)
No.186
著　者 M. Zalewski, D. Janasik, A. Kapa?a, M. Minoshima, F. Sugihara, W. Raj, J. Pietrasik, K. Kikuchi, T. Krawczyk
論文名 'pH‐Sensitive Polymethacrylates as Potential Contrast Agents in 19F MRI'
掲載誌頁 Macromolecular Chemistry and Physics, 2200027 (2022)
No.185
著　者 S. I. Reja, Y. Hori, T. Kamikawa, K. Yamasaki, M. Nishiura, S. D. Bull, K. Kikuchi
論文名 'An "OFF-ON-OFF" fluorescence protein-labeling probe for real-time visualization of the degradation of short-lived proteins in cellular systems'
掲載誌頁 Chemical Science, 13, 1419-1427 (2022)
No.184
著　者 M. Vicente, J. Salgado-Almario, M. M. Collins, A. Martinez-Sielva, M. Minoshima, K. Kikuchi, B. Domingo, J. Llopis
論文名 'Cardioluminescence in transgenic zebrafish larvae: A calcium imaging tool to study drug effects and pathological modeling'
掲載誌頁 Biomedicines, 9, 1294 (2021)
No.183
著　者 H. Tsukazaki, J. Kikuta, T. Ao, A. Morimoto, C. Fukuda, E. Tsuda, M. Minoshima, K. Kikuchi, T. Kaito, M. Ishii
論文名 'Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation'
掲載誌頁 Bone 2021, 152, 116095 (2021)
No.182
著　者 Y. Konishi, A. Okunishi, F. Sugihara, T. Nakamura, K. Akazawa, M. Minoshima, K. Kikuchi.
論文名 'Development of Off-On Switching 19F MRI Probes for Cathepsin K Activity Detection'
掲載誌頁 Bull. Chem. Soc. Jpn, 94, 1690-1694 (2021)
No.181
著　者 T. Kowada, K. Arai, A. Yoshimura, T. Matsui, K. Kikuchi, S. Mizukami.
論文名 'Optical Manipulation of Subcellular Protein Translocation Using a Photoactivatable Covalent Labeling System'
掲載誌頁 Angew. Chem. Int. Ed., 60, 11378-11383 (2021)
No.180
著　者 Y. Hori, M. Nishiura, T. Tao, R. Baba, S. D. Bull, K. Kikuchi
論文名 'Fluorogenic probes for detecting deacylase and demethylase activity towards post-translationally-modified lysine residues'
掲載誌頁 Chem. Sci., 12, 2498-2503 (2021)
No.179
著　者 M. Wyskocka-Gajda, L. Przypis, M. Olesiejuk, T. Krawczyk, A. Kuźnik, K. Nawara, M. Minoshima, F. Sugihara, K. Kikuchi, N. Kuźnik
論文名 'A Step towards Gadolinium-free Bioresponsive MRI Contrast Agent'
掲載誌頁 Eur. J. Med. Chem., 211, 113086 (2020)
No.178
著　者 H. Imamura, S. Sakamoto, T. Yoshida, Y. Matsui, S. Penuela, D.W.Laird, S. Mizukami, K. Kikuchi, A. Kakizuka
論文名 'Single-cell Dynamics of Pannexin-1-facilitated Programmed ATP Loss during Apoptosis'
掲載誌頁 eLife, 9, e61960 (2020)
No.177
著　者 M. M. Tomczyk, S. Boncel, A. Herman, T. Krawczyk, A. Jakóbik-Kolon, M. Pawlyta, M. Krywiecki, A. Chrobak, M. Minoshima, F. Sugihara, K. Kikuchi, N. Kuźnik
論文名 'Oxygen Functional Groups on MWCNT Surface as Critical Factor Boosting T2 Relaxation Rate of Water Protons: Towards Improved CNT-Based Contrast Agents'
掲載誌頁 Int. J. Nanomedicine, 15, 7433 (2020)
No.176
著　者 T. Imoto, M. Minoshima, T. Yokoyama, B. P. Emery, S. D. Bull, H. Bito, K. Kikuchi
論文名 'A Photoactivatable Antagonist for Controlling CREB Dependent Gene Expression'
掲載誌頁 ACS Cent. Sci., 6, 1813 (2020)
No.175
著　者 R. Hashimoto, M. Minoshima, J. Kikuta, S. Yari, S. D. Bull, M. Ishii, K. Kikuchi
論文名 'An Acid Activatable Fluorescence Probe for Imaging Osteocytic Bone Resorption Activity in Deep Bone Cavities'
掲載誌頁 Angew. Chem. Int. Ed., 59, 20996 (2020)
No.174
著　者 K. Torii, Y. Hori, K. Watabe, K. Kikuchi
論文名 'Development of photoswitchable fluorescent molecules using arylazopyrazole'
掲載誌頁 Bull. Chem. Soc. Jpn, 93, 821 (2020)
No.173
著　者 N. Kumar, Y. Hori, M. Nishiura, K. Kikuchi
論文名 'Rapid No-wash Labeling of PYP-tag Proteins with Reactive Fluorogenic Ligands Affords Stable Fluorescent Protein Conjugates for Long-Term Cell Imaging Studies''
掲載誌頁 Chem. Sci., 11, 3694 (2020)
No.172
著　者 M. Tanuma, A. Kasai, K. Bando, N. Kotoku, K. Harada, M. Minoshima, K. Higahino, A. Kimishima, M. Arai, Y. Ago, K. Seiriki, K. Kikuchi, S. kawata, K. Fujita, H. Hashimoto
論文名 ''Direct Visualization of an Antidepressant Analog Using Surface-enhanced Raman Scattering in the Brain''
掲載誌頁 JCI Insight, 5, e133348 (2020)
No.171
著　者 M. Weber, N. Yamada, X. Tian, S. D. Bull, M. Minoshima, K. Kikuchi, A. B. Mackenzie, T. D. James
論文名 ''Sensing Peroxynitrite in Different Organelles of Murine RAW264.7 Macrophages with Coumarin-Based Fluorescent Probes''
掲載誌頁 Front. Chem., 8, 39 (2020)
No.170
著　者 Jingchi Gao, Yuichiro Hori, Miyako Nishiura, Mathieu Bordy, Jens Hasserodt, and Kazuya Kikuchi
論文名 ''Engineered Protein-Tag for Rapid Live-Cell Fluorogenic Visualization of Proteins by Anionic Probes''
掲載誌頁 Chem. Lett., 49, 232-235 (2020)
No.169
著　者 Jingchi Gao, Yuichiro Hori, Osamu Takeuchi, and Kazuya Kikuchi
論文名 ''Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch''
掲載誌頁 Bioconjugate Chem., 31, 577-583 (2020)
No.168
著　者 Takuma Imoto, Akihiro Kawase, Masafumi Minoshima, Tatsushi Yokoyama, Haruhiko Bito and Kazuya Kikuchi
論文名 ''Photolytic Release of a Caged Inhibitor of an Endogenous Transcription Factor Enables Optochemical Control of CREB-mediated Gene Expression''
掲載誌頁 Org. Lett., 22, 22-25 (2020)
No.167
著　者 Takuma Imoto, Masayasu Muramatsu, Hiroshi Miyasaka, Shin Mizukami and Kazuya Kikuchi
論文名 ''Improvement in Photostability of Fluorescein by Lanthanide Ions Based on Energy Transfer-based Triplet State Quenching''
掲載誌頁 Chem. Lett., 48, 1181-1184 (2019)
No.166
著　者 Jingchi Gao, Yuichiro Hori, Takashi Shimomura, Mathieu Bordy, Jens Hasserodt and Kazuya Kikuchi
論文名 ''Development of Fluorogenic Probes for Rapid High-Contrast Imaging of Transient Nuclear Localization of Sirtuin 3''
掲載誌頁 ChemBioChem., 21, 656-662 (2019)
No.165
著　者 Benson, S., Fernandez, A., Barth, N., de Moliner, F., Horrocks, M., Herrington, C. S., Abad, J. L., Delgado, A., Kelly, L., Chang, Z., Feng, Y., Nishiura, M., Hori, Y., Kikuchi, K., Vendrell, M.
論文名 ''SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism''
掲載誌頁 Angew. Chem. Int. Ed., 58, 6911-6915 (2019)
No.164
著　者 Masafumi Minoshima, Junichi Kikuta, Yuta Omori, Shigeto Seno, Riko Suehara, Hiroki Maeda, Hideo Matsuda, Masaru Ishii, Kazuya Kikuchi
論文名 ''In vivo Multicolor Imaging with Fluorescent Probes Revealed the Dynamics and Function of Osteoclast Proton Pumps''
掲載誌頁 ACS Cent. Sci., 5, 6, 1059-1066 (2019)
No.163
著　者 Kazuki Akazawa, Fuminori Sugihara, Tatsuya Nakamura, Hisashi Matsushita, Hiroaki Mukai, Rena Akimoto, Masafumi Minoshima, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Perfluorocarbon-based 19F MRI Nanoprobes for In Vivo Multicolor Imaging''
掲載誌頁 Angew. Chem. Int. Ed., 57, 16742-16747. (2018)
No.162
著　者 Kazuki Akazawa, Fuminori Sugihara, Masafumi Minoshima, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Sensing Caspase-1 Activity Using Activable 19F MRI Nanoprobes with Improved Turn-on Kinetics''
掲載誌頁 Chem. Commun., 54, 11785-11788. (2018)
No.161
著　者 Junichi Kikuta, Mai Shirazaki, Takao Sudo, Hiroki Mizuno, Akito Morimoto, Riko Suehara, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii
論文名 ''Dynamic Analyses of the Short‐term Effects of Different Bisphosphonates Using Intravital Two‐photon Microscopy''
掲載誌頁 JBMR PLUS, 2, 362-366. (2018)
No.160
著　者 Yoshinobu Matsuura, Junichi Kikuta, Yuika Kishi, Tetsuo Hasegawa, Daisuke Okuzaki, Toru Hirano, Masafumi Minoshima, Kazuya Kikuchi, Atsushi Kumanogoh, Masaru Ishii
論文名 ''In Vivo Visualisation of Different Modes of Action of Biological DMARDs Inhibiting Osteoclastic Bone Resorption''
掲載誌頁 Ann. Rheum. Dis. 77, 1219-1225. (2018)
No.159
著　者 Kazuki Akazawa, Fuminori Sugihara, Tatsuya Nakamura, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Highly Sensitive Detection of Caspase-3/7 Activity in Living Mice Using Enzyme-Responsive 19F MRI Nanoprobes''
掲載誌頁 Bioconjugate Chem., 29, 1720-1728 (2018)
No.158
著　者 Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-il Chung, Alexander C. Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa and Masaru Ishii
論文名 ''Direct Cell-cell Contact Between Mature Osteoblasts and Osteoclasts Dynamically Controls Their Fucntions In Vivo''
掲載誌頁 Nat. Commun., 9, 300. (2018)
No.157
著　者 Yuichiro Hori, Norimichi Otomura, Ayuko Nishida, Miyako Nishiura, Maho Umeno, Isao Suetake, and Kazuya Kikuchi
論文名 ''Synthetic-Molecule/Protein Hybrid Probe with Fluorogenic Switch for Live-Cell Imaging of DNA Methylation''
掲載誌頁 J. Am. Chem. Soc., 140, 1686-1690. (2018)
No.156
著　者 Yusuke Matsui, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Ratiometric Imaging of Intracellular Mg2+ Dynamics Using a Red Fluorescent Turn-off Probe and a Green Fluorescent　Turn-on Probe''
掲載誌頁 Chem. Lett., 47, 23-26. (2018)
No.155
著　者 Ryota Sato, Jun Kozuka, Masahiro Ueda, Reiko Mishima, Yutaro Kumagai, Akimasa Yoshimura, Masafumi Minoshima, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Intracellular protein-labeling probes for multicolor single-molecule imaging of immune receptor-adaptor molecular dynamics''
掲載誌頁 J. Am. Chem. Soc., 139, 17397-17404 (2017)
No.154
著　者 Yuichiro Hori, Shinya Hirayama, and Kazuya Kikuchi
論文名 ''Development of cyanine probes with dinitrobenzene quencher for rapid fluorogenic protein labeling''
掲載誌頁 Philos. Trans. R. Soc. A, 375, DOI: 10.1098/rsta.2017.0018 (2017)
No.153
著　者 Yusuke Matsui, Yosuke Funato, Hiromi Imamura, Hiroaki Miki, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Visualization of Long-term Mg2+ Dynamics in Apoptotic Cells with a Novel Targetable Fluorescent Probe''
掲載誌頁 Chem. Sci., 8, 8255-8264 (2017)
No.152
著　者 Yusuke Matsui, Kalyan K. Sadhu, Shin Mizukami, and Kazuya Kikuchi
論文名 ''Highly Selective Tridentate Fluorescent Probes for Visualizing Intracellular Mg2+ Dynamics without Interference from Ca2+ Fluctuation''
掲載誌頁 Chem. Commun., 53, 10644-10647 (2017)
No.151
著　者 Shin Mizukami, Masayoshi Kashibe, Kengo Matsumoto, Yuichiro Hori, and Kazuya Kikuchi
論文名 ''Enzyme-triggered compound release using functionalized antimicrobial peptide derivatives''
掲載誌頁 Chem. Sci., 8, 3047-3053 (2017)
No.150
著　者 Shinya Hirayama, Yuichiro Hori, Zsolt Benedek, Tadashi Suzuki, and Kazuya Kikuchi
論文名 ''Fluorogenic probes reveal a role of GLUT4 N-glycosylation in intracellular trafficking''
掲載誌頁 Nat. Chem. Biol., 12, 853-859 (2016)
No.149
著　者 Hiroki Maeda, Toshiyuki Kowada, Junichi Kikuta, Masayuki Furuya, Mai Shirazaki, Shin Mizukami, Masaru Ishii, and Kazuya Kikuchi
論文名 ''Real-time intravital imaging of pH variation associated with osteoclast activity''
掲載誌頁 Nat. Chem. Biol., 12, 579-585 (2016)
No.148
著　者 Yuko Kamikawa, Yuichiro Hori, Kazuo Yamashita, Lin Jin, Shinya Hirayama, Daron M Standley and Kazuya Kikuchi
論文名 ''Design of a Protein Tag and Fluorogenic Probe with Modular Structure for Live-Cell Imaging of Intracellular Proteins''
掲載誌頁 Chem. Sci., 7, 308-314 (2016)
No.147
著　者 Yuichiro Hori, Shinya Hirayama, Motoki Sato, Kazuya Kikuchi
論文名 ''Redesign of a Fluorogenic Labeling System to Improve Surface Charge, Brightness, and Binding Kinetics for Imaging the Functional Localization of Bromodomains''
掲載誌頁 Angew. Chem. Int. Ed., 54, 14368-14371 (2015)
No.146
著　者 T. Nakamura, H. Matsushita, F. Sugihara, Y. Yoshioka, S. Mizukami, and K. Kikuchi
論文名 ''Activatable 19F MRI Nanoparticle Probes for the Detection of Reducing Environments''
掲載誌頁 Angew. Chem. Int. Ed., 54, 1007-1010 (2015)
No.145
著　者 Zhanghua Zeng, Shin Mizukami, Katsumasa Fujita, Kazuya Kikuchi
論文名 ''An Enzyme-Responsive Metal-Enhanced Near-Infrared Fluorescence Sensor Based on Functionalized Gold Nanoparticles''
掲載誌頁 Chem. Sci., 6, 4934-4939 (2015)
No.144
著　者 T. Nakamura, F. Sugihara, H. Matsushita, Y. Yoshioka, S. Mizukami, K. Kikuchi
論文名 ''Mesoporous Silica Nanoparticles for 19F Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery''
掲載誌頁 Chem. Sci., 6, 1986-1990 (2015)
No.143
著　者 R. Baba, Y. Hori, and K. Kikuchi
論文名 ''Intramolecular Long-Distance Nucleophilic Reactions as a Rapid Fluorogenic Switch Applicable to the Detection of Enzymatic Activity''
掲載誌頁 Chem. Eur. J., 21, 4695-4702 (2015)
No.142
著　者 K. Mochizuki, L. Shi, S. Mizukami, M. Yamanaka, M. Tanabe, W. Gong, A. F. Palonpon, S. Kawano, S. Kawata, K. Kikuchi, K. Fujita
論文名 ''Nonlinear Fluorescence Imaging by Using Phtoinduced Charge Separation''
掲載誌頁 Jpn. J. Appl. Phys., 54, 042403 (2015)
No.141
著　者 H. Matsushita, S. Mizukami, F. Sugihara, Y. Nakanishi, Y. Yoshioka, and K. Kikuchi
論文名 ''Multifunctional Core-shell Silica Nanoparticles for Highly Sensitive 19F Magnetic Resonance Imaging''
掲載誌頁 Angew. Chem. Int. Ed., 53, 1008-1011 (2014)
No.140
著　者 S. Okada, S. Mizukami, T. Sakata, Y. Matsumura, Y. Yoshioka, and K. Kikuchi
論文名 ''Ratiometric MRI Sensors Based on Core-Shell Nanoparticles for Quantitative pH Imaging''
掲載誌頁 Adv. Mater., 26, 2989-2992 (2014)
No.139
著　者 M. Minoshima, T. Matsumoto, and K. Kikuchi
論文名 ''Development of a Fluorogenic Probe Based on a DNA Staining Dye for Continuous Monitoring of the Histone Deacetylase Reaction''
掲載誌頁 Anal. Chem., 86, 7925-7930 (2014)
No.138
著　者 A. Yoshimura, S. Mizukami, Y. Mori, Y. Yoshioka, and K. Kikuchi
論文名 ''1H MRI Detection of Gene Expression in Living Cells by Using Protein Tag and Biotinylation Probe''
掲載誌頁 Chem. Lett., 43, 219-221 (2014)
No.137
著　者 Y. Funato, D. Yamazaki, S. Mizukami, L. Du, K. Kikuchi, H. Miki
論文名 ''Membrane Protein CNNM4-Dependent Mg2+ Efflux Suppresses Tumor Progression''
掲載誌頁 J. Clin. Invest., 124, 5398-5410 (2014)
No.136
著　者 Y. Hori, T. Norinobu, M. Sato, K. Arita, M. Shirakawa, and K. Kikuchi
論文名 ''Development of Fluorogenic Probes for Quick No-Wash Live-Cell Imaging of Intracellular Proteins''
掲載誌頁 J. Am. Chem. Soc., 135, 12360-12365 (2013) (Featured in JACS Spotlights)
No.135
著　者 E. Lindberg, S. Mizukami, K. Ibata, T. Fukano, A. Miyawaki, and K. Kikuchi
論文名 ''Development of Cell-Impermeable Coelenterazine Derivatives''
掲載誌頁 Chem. Sci., 4, 4395-4400 (2013)
No.134
著　者 E. Lindberg, S. Mizukami, K. Ibata, A. Miyawaki, and K. Kikuchi
論文名 ''Development of Luminescent Coelenterazine Derivatives Activatable by β-Galactosidase for Monitoring Dual Gene Expression''
掲載誌頁 Chem. Eur. J., 19, 14970-14976 (2013)
No.133
著　者 T. Nakamura, S. Mizukami, M. Tanaka, and K. Kikuchi
論文名 ''Efficient Development of Luminescent Lanthanide(III) Complexes by Solid-phase Synthesis and On-resin Screeing''
掲載誌頁 Chem. Asian. J., 8, 2685-2690 (2013)
No.132
著　者 S. Okada, S. Mizukami, Y. Matsumura, Y. Yoshioka, and K. Kikuchi
論文名 ''A Nanospherical Polymer as an MRI Sensor without Paramagnetic or Superparamagnetic Species''
掲載誌頁 Dalton Trans., 42, 15864-15867 (2013)
No.131
著　者 K. K. Sadhu, S. Mizukami, A. Yoshimura, and K. Kikuchi
論文名 ''pH Induced Dual "OFF-ON-OFF" Switch: Influence of a Suitably Placed Carboxylic Acid ''
掲載誌頁 Org. Biomol. Chem., 11, 563-568 (2013)
No.130
著　者 J. Kikuta, Y. Wada, T. Kowada, Z. Wang, Ge-Hong Sun-Wada, I. Nishiyama, S. Mizukami, N. Maiya, H. Yasuda, A. Kumanogoh, K. Kikuchi, R. Germain, and M. Ishii
論文名 ''Dynamic Visualization of RANKL and Th17-mediated Control of Osteoclast Function''
掲載誌頁 J. Clin. Invest., 123, 866-873 (2013)
No.129
著　者 D. Yamazaki, Y. Funato, J. Miura, S. Sato, S. Toyosawa, K. Furutani, Y. Kurachi, Y. Omori, T. Furukawa, T. Tsuda, S. Kuwabata, S. Mizukami, K. Kikuchi, and H. Miki
論文名 ''Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model''
掲載誌頁 PLOS Genet., 9, e1003983 (2013)
No.128
著　者 R. Baba, Y. Hori, S. Mizukami, and K. Kikuchi
論文名 ''Development of a Fluorogenic Probe with a Transesterification Switch for Detection of Histone Deacetylase Activity''
掲載誌頁 J. Am. Chem. Soc., 134, 14310-14313 (2012) (Featured in JACS Spotlights)
No.127
著　者 S. Mizukami, S. Watanabe, Y. Akimoto, and K. Kikuchi
論文名 ''No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis''
掲載誌頁 J. Am. Chem. Soc., 134, 1623-1629 (2012)
No.126
著　者 Y. Hori, K. Nakaki, M. Sato, S. Mizukami, and K. Kikuchi
論文名 ''Development of Protein Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association and No-wash Live-cell Imaging''
掲載誌頁 Angew. Chem. Int. Ed., 51, 5611-5614 (2012)
No.125
著　者 K. Dhara, Y. Hori, R. Baba, and K. Kikuchi
論文名 ''A Fluorescent Probe for Detection of Histone Deacetylase Activity Based on Aggregation-induced Emission''
掲載誌頁 Chem. Commun., 48, 11534-11536 (2012)
No.124
著　者 Z. Zeng, S. Mizukami, and K. Kikuchi
論文名 ''Simple and Real-time Colorimetric Assay for Glycosidases Activity Using Functionalized Gold Nanoparticles and its Application for Inhibitor Screening''
掲載誌頁 Anal. Chem., 48, 11534-11536 (2012)
No.123
著　者 H. Matsushita, S. Mizukami, Y. Mori, F. Sugihara, M. Shirakawa, Y. Yoshioka, and K. Kikuchi
論文名 ''19F MRI monitoring of Gene Expression in Living Cells via Cell Surface β-Lactamase Activity''
掲載誌頁 ChemBioChem, 13, 1579-1583 (2012)
No.122
著　者 S. Okada, S. Mizukami, and K. Kikuchi
論文名 ''Switchable MRI Contrast Agents Based on Morphological Changes of pH-Responsive Polymers''
掲載誌頁 Bioorg. Med. Chem., 20, 769-774 (2012)
No.121
著　者 K. K. Sadhu, S. Mizukami, C. R. Lanam, and K. Kikuchi
論文名 ''A New Approach for Fluorogenic Protein Labeling via Photoinduced Electron Transfer Based BL-tag Protein Labeling Method''
掲載誌頁 Chem. Asian J., 7, 272-276 (2012)
No.120
著　者 T. Terai, H. Ito, K. Kikuchi, and T. Nagano
論文名 ''Salicylic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes''
掲載誌頁 Chem. Eur. J., 18, 7377-7381 (2012)
No.119
著　者 T. Terai, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano
論文名 ''A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase(NAT) Activity of Cells''
掲載誌頁 Chem. Commun., 48, 2234-2236 (2012)
No.118
著　者 T. Kowada, J. Kikuta, A. Kubo, M. Ishii, H. Maeda, S. Mizukami, and K. Kikuchi
論文名 ''In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts''
掲載誌頁 J. Am. Chem. Soc., 133, 17772-17776 (2011)
No.117
著　者 S. Mizukami, T. Yamamoto, A. Yoshimura, S. Watanabe, and K. Kikuchi
論文名 ''Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-based Multicolor Bioimaging''
掲載誌頁 Angew. Chem. Int. Ed., 50, 8750-8752 (2011)
No.116
著　者 S. Watanabe, S. Mizukami, Y. Akimoto, Y. Hori, and K. Kikuchi
論文名 ''Intracellular Protein Labeling with Prodrug-Like Probes Based on Mutant β-Lactamase-Tag''
掲載誌頁 Chem. Eur. J., 17, 8342-8349 (2011)
No.115
著　者 K. K. Sadhu, S. Mizukami, S. Watanabe, and K. Kikuchi
論文名 ''Sequential Ordering among Multicolor Fluorophores for Protein Labeling Facility Aggregation-Elimination Based β-Lactam Probes''
掲載誌頁 Mol. BioSyst., 7, 1766-1772 (2011).
No.114
著　者 S. Mizukami, H. Matsushita, R. Takikawa, F. Sugihara, M. Shirakawa, and K. Kikuchi
論文名 ''19F MRI Detection of β-Galactosidase Activity for Imaging of Gene Expression''
掲載誌頁 Chem. Sci., 2, 1151-1155 (2011)
No.113
著　者 A. Yoshimura, S. Mizukami, Y. Hori, S. Watanabe, and K. Kikuchi
論文名 ''Cell Surface Protein Labeling with Luminescent Nanoparticles via Biotinylation Using Mutant β-Lactamase-tag Technology''
掲載誌頁 ChemBioChem, 12, 1031-1034 (2011)
No.118
著　者 T. Kowada, J. Kikuta, A. Kubo, M. Ishii, H. Maeda, S. Mizukami, and K. Kikuchi
論文名 ''In Vivo Fluorescence Imaging of Bone-Resorbing Osteoclasts''
掲載誌頁 J. Am. Chem. Soc., 133, 17772-17776 (2011)
No.117
著　者 S. Mizukami, T. Yamamoto, A. Yoshimura, S. Watanabe, and K. Kikuchi
論文名 ''Covalent Protein Labeling with a Lanthanide Complex and its Application to Photoluminescence Lifetime-based Multicolor Bioimaging''
掲載誌頁 Angew. Chem. Int. Ed., 50, 8750-8752 (2011)
No.116
著　者 S. Watanabe, S. Mizukami, Y. Akimoto, Y. Hori, and K. Kikuchi
論文名 ''Intracellular Protein Labeling with Prodrug-Like Probes Based on Mutant β-Lactamase-Tag''
掲載誌頁 Chem. Eur. J., 17, 8342-8349 (2011)
No.115
著　者 K. K. Sadhu, S. Mizukami, S. Watanabe, and K. Kikuchi
論文名 ''Sequential Ordering among Multicolor Fluorophores for Protein Labeling Facility Aggregation-Elimination Based β-Lactam Probes''
掲載誌頁 Mol. BioSyst., 7, 1766-1772 (2011).
No.114
著　者 S. Mizukami, H. Matsushita, R. Takikawa, F. Sugihara, M. Shirakawa, and K. Kikuchi
論文名 ''19F MRI Detection of β-Galactosidase Activity for Imaging of Gene Expression''
掲載誌頁 Chem. Sci., 2, 1151-1155 (2011)
No.113
著　者 A. Yoshimura, S. Mizukami, Y. Hori, S. Watanabe, and K. Kikuchi
論文名 ''Cell Surface Protein Labeling with Luminescent Nanoparticles via Biotinylation Using Mutant β-Lactamase-tag Technology''
掲載誌頁 ChemBioChem, 12, 1031-1034 (2011)
No.112
著　者 S. Mizukami, M. Hosoda, T. Satake, S. Okada, Y. Hori, T. Furuta, and K. Kikuchi
論文名 ''Photocontrolled Compound Release System Using Caged Antimicrobial Peptide''
掲載誌頁 J. Am. Chem. Soc., 132, 9524-9525 (2010)
No.111
著　者 K. K. Sadhu, S. Mizukami, S Watanabe, and K. Kikuchi
論文名 ''Turn-on Fluorescent Switch Involving Aggregation and Elimination Processes for β-Lactamase-Tag''
掲載誌頁 Chem. Commun., 46, 7403-7405 (2010)
No.110
著　者 S. Watanabe, S. Mizukami, Y. Hori, and K. Kikuchi
論文名 ''Multicolor Protein Labeling in Living Cells Using Mutant β-Lactamase-Tag Technology''
掲載誌頁 Bioconjug. Chem., 21, 2320-2326. (2010)
No.109
著　者 S. Okada, S. Mizukami, and K. Kikuchi
論文名 ''Application of a Stimuli-responsive Polymer to the Development of Novel MRI Probes''
掲載誌頁 ChemBioChem., 11, 785-787 (2010)
No.108
著　者 Y. Hori, Y. Egashira, R. Kamiura, and K. Kikuch
論文名 ''Noncovalent-interaction-promoted Ligation for Protein Labeling''
掲載誌頁 ChemBioChem., 11, 646-648 (2010)
No.107
著　者 Y. Hori, H. Ueno, S. Mizukami, and K. Kikuchi
論文名 ''Photoactive Yellow Protein-Based Protein Labeling System with Turn-On Fluorescence Intensity''
掲載誌頁 J. Am. Chem. Soc., 131, 16610-16111 (2009)
No.106
著　者 S. Mizukami, S. Watanabe, Y. Hori, and K. Kikuchi
論文名 ''Covalent Protein Labeling Based on Non-catalytic β-lactamase and a Designed FRET Substrate''
掲載誌頁 J. Am. Chem. Soc., 131, 5016-5017 (2009)
No.105
著　者 S. Mizukami, R. Takikawa, F. Sugihara, M. Shirakawa, and K. Kikuchi
論文名 ''Dual Functional Probe to Detect Protease Activity for Fluorescence Measurement and 19F MRI''
掲載誌頁 Angew. Chem. Int. Ed., 48, 3641-3643 (2009)
No.104
著　者 S. Mizukami, S. Okada, S. Kimura, and K. Kikuchi
論文名 ''Design and Synthesis of Coumarin-based Zn2+ Probes for Ratiometric Fluorescence Imaging''
掲載誌頁 Inorg. Chem.,48, 7630-7638 (2009)
No.103
著　者 S. Mizukami, S. Watanabe, and K. Kikuchi
論文名 ''Development of Ratiometric Fluorescent Probes for Phosphatases Using pKa-Switching Mechanism''
掲載誌頁 ChemBioChem,10, 1465-1468 (2009)
No.102
著　者 K. Kikuchi, S. Hashimoto, S. Mizukami, and T. Nagano
論文名 ''Anion Sensor-Based Ratiometric Peptide Probe for Protein Kinase Activity''
掲載誌頁 Org. Lett.,11, 2732-2735 (2009)
No.101
著　者 S. Yamaguchi, C. Miura, F. T. Celino, T. Agusa, S. Tanabe, K. Kikuchi, and T. Miura
論文名 ''Zinc is an essential trace element for spermatogenesis''
掲載誌頁 Proc. Natl. Acad. Sci. U.S.A.106, 10859-10864 (2009)
No.100
著　者 S. Mizukami, K. Tonai, M. Kaneko, and K. Kikuchi
論文名 ''Lanthanide-Based Protease Activity Sensors for Time-Resolved Fluorescence Measurements''
掲載誌頁 J. Am. Chem. Soc., 130, 14376-14377 (2008)
No.99
著　者 S. Mizukami, R. Takikawa, F. Sugihara, Y. Hori, H. Tochio, M. Walchli, M. Shirakawa, and K. Kikuchi
論文名 ''Paramagnetic Relaxation-based 19F MRI Probe to Detect Protease Activity''
掲載誌頁 J. Am. Chem. Soc.,130, 794-795 (2008)
No.98
著　者 R. A. Colvin, A. L. Bush, I. Volitakis, C. P. Fontaine, D. Thomas, K. Kikuchi, and W. R. Holmes
論文名 ''Insights into Zn2+ Homeostasis in Neurons from Experimental and Modeling Studies''
掲載誌頁 Am. J. Physiol., Cell Physiol., 294, C726-C742 (2008)
No.97
著　者 T. Yogo, Y. Urano, A. Mizushima, H. Sunahara, T. Inoue, K. Hirose, M. Iino, K. Kikuchi, and T. Nagano
論文名 ''Selective Photoinactivation of Protein Function through Environment- sensitive Switching of Singlet Oxygen Generation by Photosensitizer''
掲載誌頁 Proc. Natl. Acad. Sci. U.S.A., 105, 28-32 (2008)
No.96
著　者 K. Hanaoka, K. Kikuchi, T. Terai, T. Komatsu, and T. Nagano
論文名 ''A Gd3+-Based Magnetic Resonance Imaging Contrast Agent Sensitive to beta-Galactosidase Activity Utilizing a Receptor-Induced Magnetization Enhancement (RIME)''
掲載誌頁 Chem. Eur. J., 18, 987-995 (2008)
No.95
著　者 K. Hanaoaka, K. Kikuchi, S. Kobayashi, and T. Nagano
論文名 ''A Time-resolved Long-lived Luminescence Imaging Method Employing Luminescent Lanthanide Probes with a New Microscopy System''
掲載誌頁 J. Am. Chem. Soc., 129, 13502-13509 (2007)
No.94
著　者 M. Kumagai, Y. Imai, T. Nakamura, Y. Yamasaki, M. Sekino, S. Ueno, K. Hanaoka, K. Kikuchi, T. Nagano, E. Kaneko, K. Shimokado, and K. Kataoka
論文名 ''Iron Hydroxide Nanoparticles Coated with Poly(ethylene glycol)-poly(aspartic acid) BlockCopolymer as Novel Magnetic Resonance Contrast Agents for in Vivo Cancer Imaging''
掲載誌頁 Coll. Surf. B-Bioint., 56, 174-181 (2007)
No.93
著　者 T. Komatsu, K. Kikuchi, H. Takakusa, K. Hanaoka, T. Ueno, M. Kamiya, Y. Urano, and T. Nagano
論文名 ''Design and Synthesis of an Enzyme Activity-Based Labeling Molecule with FluorescenceSpectral Change''
掲載誌頁 J. Am. Chem. Soc., 128, 6938-6946 (2006)
No.92
著　者 T. Terai, K. Kikuchi, S. Iwasawa, T. Kawabe, Y. Hirata, Y. Urano, and T. Nagano
論文名 ''Modulation of Luminescence Intensity of Lanthanide Complexes by PhotoinducedElectron Transfer and Its Application to a Long-Lived Protease Probe''
掲載誌頁 J. Am. Chem. Soc., 128, 6938-6946 (2006)
No.91
著　者 G. Crivat, K. Kikuchi, T. Nagano, T. Priel, M. Hershfinkel, I. Sekler, N. Rozenzweig, and Z. Rosenzweig
論文名 ''Fluorescence-based Zinc Ion Sensor for Zinc Ion Release from Pancreatic Cells''
掲載誌頁 Anal. Chem., 78, 5799-5804 (2006)
No.90
著　者 A. Minami, N. Sakurada, S. Fuke, K. Kikuchi, T. Nagano, N. Oku, and A. Takeda
論文名 ''Inhibition of Presynaptic Activity by Zinc Released From Mossy Terminals During Tetanic Stimulation''
掲載誌頁 J. Neurosci. Res., 83, 167-176 (2006)
No.89
著　者 K. Kikuchi, R. B. Hannak, M. J. Guo, A. J. Kirby, and D. Hilvert
論文名 ''Toward Bifunctional Antibody Catalysis''
掲載誌頁 Bioorg. Med. Chem., 14, 6189-6196 (2006)
No.88
著　者 S. Mizukami, T. W. Kim, S. Helquist, and E. T. Kool
論文名 ''Varying DNA Base Pair Size in Sub-Angstrom Increments: Evidence for a Loose, Not Large, Active Site in Low-fidelity Dpo4 Polymerase''
掲載誌頁 Biochemistry, 45, 2772-2778 (2006)
No.87
著　者 K. Komatsu, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano
論文名 ''Selective Zinc Sensor Molecules with Various Affinities for Zn2+, Revealing Dynamics and Regional Distribution of Synaptically Released Zn2+ in Hippocampal Slices''
掲載誌頁 J. Am. Chem. Soc., 127, 10197-10204 (2005)
(ACS National Chemistry Week 2006において100 Current Hot Papersに選定された)
No.86
著　者 E. Kawabata, K. Kikuchi, Y. Urano, H. Kojima, A. Odani, and T. Nagano
論文名 ''Design and Synthesis of Zinc-Selective Chelators for Extracellular Applications''
掲載誌頁 J. Am. Chem. Soc., 127, 818-819 (2005)
No.85
著　者 L.A. van Meeteren, P. Ruurs, E. Christodoulou, J.W. Goding, H. Takakusa, K. Kikuchi, A. Perrakis, T. Nagano, and W.H. Moolenaar
論文名 ''Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine-1-phosphate''
掲載誌頁 J. Biol. Chem., 280, 21155-21161 (2005)
No.84
著　者 R. A. Colvin, P. Fontaine, D. Thomas, T. Hirano, T. Nagano, and K. Kikuchi
論文名 ''Evidence for pH Dependent Zn2+ Influx in K562 Erythroleukemia Cells: Studies Using ZnAF-2F Fluorescence and Zn-65(2+) Uptaker''
掲載誌頁 Arch. Biochem. Biophys., 442, 222-228 (2005)
No.83
著　者 E. Sasaki, H. Kojima, H. Nishimatsu, Y. Urano, K. Kikuchi, Y. Hirata, and T. Nagano
論文名 ''Highly Sensitive Near-infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs''
掲載誌頁 J. Am. Chem. Soc., 127, 3684-3685 (2005)
No.82
著　者 S. Mizukami, H. Houjou, K. Sugaya, H. Tokuhisa, E. Koyama, T. Sasaki, and M. Kanesato
論文名 ''Fluorescence Color Modulation by Intramolecular and Intermolecular p-p Interactions in a Helical Zinc(II) Complex''
掲載誌頁 Chem. Mater., 17, 50-56 (2005)
No.81
著　者 K. Hanaoka, K. Kikuchi, H. Kojima, Y. Urano, and T. Nagano
論文名 ''Development of a Zinc Ion-selective Luminescent Lanthanide Chemosensor for Biological Applications''
掲載誌頁 J. Am. Chem. Soc., 126, 12470-12476 (2004)
No.80
著　者 T. Yogo, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano
論文名 ''Modification of Intracellular Ca2+ Dynamics by Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptor Using Membrane-permeant Probes''
掲載誌頁 Chemistry & Biology, 11, 1053-1058 (2004)
No.79
著　者 Y. Hu, K. N. Houk, K. Kikuchi, K. Hotta, and D. Hilvert
論文名 ''Nonspecific Medium Effects versus Specific Group Positioning in the Antibody and Albumin Catalysis of the Base-Promoted Ring-Opening Reactions of Benzisoxazoles''
掲載誌頁 J. Am. Chem. Soc., 126, 8197-8205 (2004)
No.78
著　者 D. Okada, C. C. Yap, H. Kojima, K. Kikuchi, and T. Nagano
論文名 ''Distinct Glutamate Receptors Govern Differential Levels of Nitric Oxide Production in a Layer-specific Manner in the Rat Cerebellar Cortex''
掲載誌頁 Neuroscience, 125, 461-472 (2004)
No.77
著　者 Y. Gabe, Y. Urano, K. Kikuchi, H. Kojima, and T. Nagano
論文名 ''Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore -Rational Design of Potentially Useful Bioimaging Fluorescence Probe''
掲載誌頁 J. Am. Chem. Soc., 126, 3357-3367 (2004)
No.76
著　者 S. Kenmoku, Y. Urano, K. Kanda, H. Kojima, K. Kikuchi, and T. Nagano
論文名 ''Rational Design of Novel Photoinduced Electron Transfer Type Fluorescent Probes forSodium Cation''
掲載誌頁 Tetrahedron, 60, 11067-11073 (2004)
No.75
著　者 T. Ueno, Y. Urano, K. Setsukinai, H. Takakusa, H. Kojima, K. Kikuchi, K. Ohkubo, S. Fukuzumi, and T. Nagano
論文名 ''Rational Principles for Modulating Fluorescence Properties of Fluorescein''
掲載誌頁 J. Am. Chem. Soc., 126, 14079-14085 (2004)
No.74
著　者 H. Koutaka, J. Kosuge, N. Fukasaku, T. Hirano, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano
論文名 ''A Novel Fluorescent Probe for Zinc Ion Based on Boron Dipyrromethene (BODIPY) Chromophore''
掲載誌頁 Chem. Pharm. Bull., 52, 700-703 (2004)
No.73
著　者 M. Kanesato, S. Mizukami, H. Houjou, H. Tokuhisa, and E. Koyama
論文名 ''Comparison of the Bond Lengths for the Lanthanide Complexes of Tripodal Heptadentate Ligands''
掲載誌頁 J. Alloys Compd., 374, 307-310 (2004)
No.72
著　者 M. Morisawa, K. Komatsu, T. Togo, S. Morisawa, K. Kikuchi, and T. Nagano
論文名 ''Role of Zinc Ion on the Initiation of Sperm Motility in Starfish''
掲載誌頁 Zoo. Sci., 21, 1284-1284 (2004)
No.71
著　者 K. Hanaoka, K. Kikuchi, H. Kojima, Y. Urano, and T. Nagano
論文名 ''Selective Detection of Zinc Ions with Novel Luminescent Lanthanide Probess''
掲載誌頁 Angew. Chem. Int. Ed., 42, 2996-2999 (2003)
No.70
著　者 T. Inoue, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano
論文名 ''Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes''
掲載誌頁 Chemistry & Biology, 10, 503-509 (2003)
No.69
著　者 H. Takakusa, K. Kikuchi, Y. Urano, H. Kojima, and T. Nagano
論文名 ''A Novel Design Method of Ratiometric Fluorescent Probes Based on Fluorescence Resonance Energy Transfer Switching by Spectral Overlap Integral''
掲載誌頁 Chem. Eur. J., 9, 1479-1485 (2003)
No.68
著　者 T. Shoda, K. Kikuchi, H. Kojima, Y. Urano, H. Komatsu, K. Suzuki, and T. Nagano
論文名 ''Development of Selective, Visible Light-excitable, Fluorescent Magnesium Probes with a Novel Fluorescence Switching Mechanism''
掲載誌頁 The Analyst, 128, 719-723 (2003)
No.67
著　者 S. Mizukami, H. Houjou, Y. Nagawa, and M. Kanesato
論文名 ''First Helical Zinc(II) Complex with a Salen Ligand''
掲載誌頁 Chem. Commun. 2003, 1148-1149
No.66
著　者 S. Mizukami, H. Houjou, M. Kanesato, and K. Hiratani
論文名 ''Adjustment of Twist Angles in Pseudo-helical Lanthanide Complexes by the Size of Metal Ions''
掲載誌頁 Chem. Eur. J., 9, 1521-1528 (2003)
No.65
著　者 S. Mizukami, T. Nagano, Y. Urano, A. Odani, and K. Kikuchi
論文名 ''A Fluorescent Anion Sensor That Works in Neutral Aqueous Solution for Bioanalytical Application''
掲載誌頁 J. Am. Chem. Soc., 124, 3920-3925 (2002)
No.64
著　者 T. Hirano, K. Kikuchi, Y. Urano, and T. Nagano
論文名 ''Improved Fluorescent Probes for Zinc, ZnAFs, Suitable for Biological Applications''
掲載誌頁 J. Am. Chem. Soc., 124, 6555-6562 (2002)
No.63
著　者 H. Takakusa, K. Kikuchi, Y. Urano, S. Sakamoto, K. Yamaguchi, and T. Nagano
論文名 ''Design and Synthesis of an Enzyme-Cleavable Sensor Molecule for Phosphodiesterase Activity Based on Fluorescence Resonance Energy Transfer''
掲載誌頁 J. Am. Chem. Soc., 124, 1653-1657 (2002)
No.62
著　者 S. Maruyama, K. Kikuchi, T. Hirano, Y. Urano, and T. Nagano
論文名 ''A Novel, Cell-Permeable, Fluorescent Probe for Ratiometric Imaging of Zinc Ion"''
掲載誌頁 J. Am. Chem. Soc., 124, 10650-10651 (2002)
No.61
著　者 S. Ueno, M. Tsukamoto, T. Hirano, K. Kikuchi, M. K. Yamada, N. Nishiyama, T. Nagano, N.Matsuki, and Y. Ikegaya
論文名 ''Mossy Fiber Zn2+Spillover Modulates Heterosynaptic N-methyl-D-aspartate Receptor Activity in Hippocampel CA3 Circuits''
掲載誌頁 J. Cell Biology, 158, 215-220 (2002)
No.60
著　者 K. Hanaoka, K. Kikuchi, Y. Urano, M. Narazaki, T. Yokawa, S. Sakamoto, K. Yamaguchi, and T. Nagano
論文名 ''Design and Synthesis of a Novel Magnetic Resonance Imaging Contrast Agent for Selective Sensing of Zinc Ion''
掲載誌頁 Chemistry & Biology, 9, 1027-1032 (2002)
No.59
著　者 N. Suzuki, H. Kojima, Y. Urano, K. Kikuchi, Y. Hirata, and T. Nagano
論文名 ''Orthogonality of Calcium Concentration and Ability of 4,5-Diaminofluorescein (DAF-2) to Detect NO''
掲載誌頁 J. Biol. Chem., 277, 47-49 (2002)
No.58
著　者 W. Nakanishi, K. Kikuchi, T. Inoue, K. Hirose, M. Iino, and T. Nagano
論文名 ''Hydrophobic Modifications at 1-Phosphate of Inositol 1,4,5-Trisphosphate Analogues Enhance Receptor Binding''
掲載誌頁 Bioorg. Med. Chem. Lett., 12, 911-913 (2002)
No.57
著　者 Y. Hori and Y. Sugiura
論文名 ''Conversion of Antennapedia Homeodomain to Zinc Finger-like Domain: Zn(II)-Induced Change in Protein Conformation and DNA Binding''
掲載誌頁 J. Am. Chem. Soc. 124, 9362-9363 (2002)
No.56
著　者 T. Inoue, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano
論文名 ''Small Molecule-based Laser Inactivation of Inositol 1,4,5-Triphosphate Receptor''
掲載誌頁 Chemistry & Biology, 8, 9-15 (2001)
No.55
著　者 H. Takakusa, K. Kikuchi, Y. Urano, T. Higuchi, and T. Nagano
論文名 ''Intramolecular Fluorescence Resonance Energy Transfer System with Coumarin Donor Included in beta-Cyclodextrin''
掲載誌頁 Anal. Chem., 73, 939-942 (2001)
No.54
著　者 K. Hanaoka, K. Kikuchi, Y. Urano, and T. Nagano
論文名 ''Selective Sensing of Zinc Ion with A Nobel Magnetic Resonance Imaging Contrast Agent''
掲載誌頁 J. Chem. Soc., Perk. Trans. 2, 1840-1843 (2001)
No.53
著　者 H. Kojima, M. Hirotani, N. Nakatsubo, K. Kikuchi, Y. Urano, T. Higuchi, Y. Hirata, and T. Nagano
論文名 ''Bioimaging of Nitric Oxide with Fluorescent Indicators Based on Rhodamine Chromophore''
掲載誌頁 Anal. Chem., 73, 1967-1973 (2001)
No.52
著　者 H. Kojima, M. Hirata, Y. Kudo, K. Kikuchi, and T. Nagano
論文名 ''Visualization of Oxygen Concentration-dependent Production of Nitric Oxide in Rat Hippocampal Slices During Aglycemia''
掲載誌頁 J. Neurochem., 76, 1404-1410 (2001)
No.51
著　者 K. Tanaka, T. Miura, N. Umezawa, Y. Urano, K.Kikuchi, T. Higuchi, and T. Nagano
論文名 ''Rational Design of Fluorescein-based Fluorescence Probes. -Mechanism-based Design of a Maximum Fluorescence Probe for Singlet Oxygen-''
掲載誌頁 J. Am. Chem. Soc., 123, 2530-2536 (2001)
No.50
著　者 J. M. Park, T. Higuchi, K. Kikuchi, Y. Urano, H. Hori, T. Nishino, J. Aoki, K. Inoue, and T. Nagano
論文名 ''Selective Inhibition of Human Inducible Nitric Oxide Synthase by S-Alkyl-L-isothiocitrulline-containing Dipeptides''
掲載誌頁 Br. J. Pharmacol., 132, 1876-1882 (2001)
No.49
著　者 M. Nagaoka, T. Kaji, M. Imanishi, Y. Hori, W. Nomura, and Y. Sugiura
論文名 ''Multi-Connection of Identical Zinc Finger: Implication for DNA Binding Affinity and Unit Modulation of Three Zinc Finger Domain''
掲載誌頁 Biochemistry 40, 2932-2941(2001)
No.48
著　者 T. Hirano, K. Kikuchi, Y. Urano, T. Higuchi, and T. Nagano
論文名 ''Highly Zinc-selective Fluorescent Sensor Molecules Suitable for Biological Applications''
掲載誌頁 J. Am. Chem. Soc., 122, 12399-12400 (2000)
No.47
著　者 Y. Kawanishi, K. Kikuchi, H. Takakusa, S. Mizukami, Y. Urano, T. Higuchi, and T. Nagano
論文名 ''Design and Synthesis of Intramolecular Resonance Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution''
掲載誌頁 Angew. Chem. Int. Ed., 39, 3438-3440 (2000)
No.46
著　者 T. Hirano, K. Kikuchi, Y. Urano, T. Higuchi, and T. Nagano
論文名 ''Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications''
掲載誌頁 Angew. Chem. Int. Ed., 39, 1052-1054 (2000)
No.45
著　者 M. Koresawa, K. Kikuchi, S. Mizukami, H. Kojima, Y. Urano, T. Higuchi, and T. Nagano
論文名 ''Development of Time-resolved Fluorometric Detection System Using Diffusion-enhanced Energy Transfer''
掲載誌頁 Anal. Chem., 72, 4904-4907 (2000)
No.44
著　者 K. Hotta, K. Kikuchi, and D. Hilvert
論文名 ''Decarboxylation of 3-Carboxybenzisoxazoles by Hydrophobic Antibody Binding Pockets''
掲載誌頁 Helv. Chem. Acta, 83, 2183-2191 (2000)
No.43
著　者 F. Hollfelder, A. J. Kirby, D. S. Tawfik, K. Kikuchi, and D. Hilvert
論文名 ''Characterization of Proton-Transfer Catalysis by Serum Albumins''
掲載誌頁 J. Am. Chem. Soc., 122, 1022-1029 (2000)
No.42
著　者 H. Kojima, M. Hirotani, Y. Urano, K. Kikuchi, T. Higuchi, and T. Nagano
論文名 ''Fluorescent Indicators for Nitric Oxide Based on Rhodamine Chromophore''
掲載誌頁 Tetrahedron Lett., 41, 69-72 (2000)
No.41
著　者 M. Kakoki, Y. Hirata, H. Hayakawa, E. Suzuki, D. Nagata, A. Tojo, H. Nishimatsu, K. Kikuchi, T. Nagano, and M. Omata
論文名 ''Effects of Tetrahydrobiopterin on Endothelial Dysfunction in Rats with Ischemic Acute Renal Failure''
掲載誌頁 J. Am. Soc. Nephrol., 11, 301-309 (2000)
No.40
著　者 T. Ohno, N. Suzuki, T. Dokoh, Y. Urano, K. Kikuchi, M. Hirobe, T. Higuchi, and T. Nagano
論文名 ''Remarkable Axial Thiolate Ligand Effects on the Oxidation of Hydrocarbons by Active Intermediate of Iron Porphyrin and Cytochrome P450''
掲載誌頁 J. Inorg. Biochem., 82, 123-125 (2000)
No.39
著　者 M. Tamura, Y. Urano, K. Kikuchi, T. Higuchi, M. Hirobe, and T. Nagano
論文名 ''Synthesis and Superoxide Dismutase Activity of Novel Iron Complexes''
掲載誌頁 J. Organomet. Chem., 611, 586-592 (2000)
No.38
著　者 M. Tamura, Y. Urano, K. Kikuchi, T. Higuchi, M. Hirobe, and T. Nagano
論文名 ''Superoxide Dismutase Activity of Iron(II) TPEN Complex and Its Derivatives''
掲載誌頁 Chem. Pharm. Bull., 48, 1514-1518 (2000)
No.37
著　者 T. Dokoh, N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi, and T. Nagano
論文名 ''A New Thioether-ligated Iron Porphyrin as a Model of a Protonated Form of P450 Active Site''
掲載誌頁 J. Inorg. Biochem., 82, 127-132 (2000)
No.36
著　者 K. Setsukinai, Y. Urano, K. Kikuchi, T. Higuchi, and T. Nagano
論文名 ''Fluorescence Switching by O-Dearylation of 7-Aryloxycoumarins.-Development of Novel Fluorescence Probes to Detect Reactive Oxygen Species With High Selectivity''
掲載誌頁 J. Chem. Soc. Perk. Trans. 2, 2453-2457 (2000)
No.35
著　者 N. Suzuki, T. Higuchi, Y. Urano, K. Kikuchi, T. Uchida, M. Mukai, T. Kitagawa, and T. Nagano
論文名 ''First Synthetic NO-heme-thiolate Complex Relevant to Nitric Oxide Synthase and Cytochrome P450nor''
掲載誌頁 J. Am. Chem. Soc., 122, 12059-12062 (2000)
No.34
著　者 Y. Hori, K. Suzuki, Y. Okuno, M. Nagaoka, S. Futaki, and Y. Sugiura
論文名 ''Artificial Zinc Finger Peptide Containing a Novel His4 Domain''
掲載誌頁 J. Am. Chem. Soc. 122, 7648-7653 (2000)
No.33
著　者 M. Imanishi, Y. Hori, M. Nagaoka, and Y. Sugiura
論文名 ''DNA-Bending Finger: Artificial Design of 6-Zinc Finger Peptides with Polyglycine Linker and Induction of DNA Bending''
掲載誌頁 Biochemistry 39, 4383-4390(2000)
No.32
著　者 S. Mizukami, K. Kikuchi, T. Higuchi, Y. Urano, T. Mashima, T. Tsuruo, and T. Nagano
論文名 "Imaging of Caspase-3 Activation in HeLa Cells Stimulated with Etoposide Using a Novel Fluorescent Probe"
掲載誌頁 FEBS Lett., 453, 356-360 (1999)
No.31
著　者 T. Inoue, K. Kikuchi, K. Hirose, M. Iino, and T. Nagano
論文名 "Synthesis and Evaluation of 1-Position-modified Inositol 1,4,5-Trisphosphate Analogs"
掲載誌頁 Bioorg. Med. Chem. Lett., 9, 1697-1702 (1999)
No.30
著　者 N. Umezawa, K. Tanaka, Y. Urano, K. Kikuchi, T. Higuchi, and T. Nagano
論文名 ''Novel Fluorescent Probes for Singlet Oxygen''
掲載誌頁 Angew. Chem. Int. Ed., 38, 2899-2901 (1999)
No.29
著　者 H. Kojima, Y. Urano, K. Kikuchi, T. Higuchi, and T. Nagano
論文名 ''Fluorescent Indicators for Imaging Nitric Oxide Production''
掲載誌頁 Angew. Chem. Int. Ed., 38, 3209-3212 (1999)
No.28
著　者 H, Kojima, N. Nakatsubo, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata, and T. Nagano
論文名 ''Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators''
掲載誌頁 Anal. Chem., 70, 2446-2453 (1998)
No.27
著　者 M. Kakoki, Y. Hirata, H. Hayakawa, A. Tojo, D. Nagata, E. Suzuki, K. Kimura, A. Goto, K. Kikuchi, T. Nagano, and M. Omata
論文名 ''Effects of Hypertension, Diabetes Mellitus and Hypercholesterolemia on Endothelin Type B Receptor-mediated Nitric Oxide Release from Rat Kidney''
掲載誌頁 Circulation, 99, 1242-1248 (1999)
No.26
著　者 H. Hayakawa, Y. Hirata, M. Kakoki, Y. Suzuki, H. Nishimatsu, D. Nagata, E. Suzuki, K. Kikuchi, T. Nagano, K. Kangawa, H. Matsuo, T. Sugimoto, and M. Omata
論文名 ''Role of Nitric Oxide-cGMP Pathway in Adrenomedullin-induced Vasodilation in Rat''
掲載誌頁 Hypertension, 33, 689-693 (1999)
No.25
著　者 M. Kakoki, Y. Hirata, H. Hayakawa, H. Nishimatsu, Y. Suzuki, D. Nagata, E. Suzuki, K. Kikuchi, T. Nagano, and M. Omata
論文名 ''Effects of Vasodilatory b-Adrenoceptor Antagonists on Endothelium-Derived Nitric Oxide Release in Rat Kidney''
掲載誌頁 Hypertension, 33, 467-471 (1999)
No.24
著　者 N. Kobayashi, T. Higuchi, Y. Urano, K.Kikuchi, M. Hirobe, and T. Nagano
論文名 ''Dipeptides Containing L-Arginine Analogs: New Isozyme-selective Inhibitors of Nitric Oxide Synthase''
掲載誌頁 Biol. Pharm. Bull., 22, 936-940 (1999)
No.23
著　者 N. Suzuki, T. Higuchi, Y. Urano, K.Kikuchi, H. Uekusa, Y. Ohashi, T. Uchida, T. Kitagawa, and T. Nagano
論文名 ''Novel Iron Porphyrin-alkanethiolate Complex with Intramolecular NH...S Hydrogen Bond: Synthesis, Spectroscopy and Reactivity''
掲載誌頁 J. Am. Chem. Soc., 121, 11571-11572 (1999)
No.22
著　者 H. Nakagawa, T. Higuchi, K. Kikuchi, Y. Urano, and T. Nagano
論文名 ''Selective Deoxygenation of Heteroaromatic N-Oxides with Olefins Catalyzed by Ruthenium Porphyrin''
掲載誌頁 Chem. Pharm. Bull., 46, 1656-1657 (1998)
No.21
著　者 H. Kurumatani, K. Kikuchi, T. Nagano, M. Hirobe, J. Yamazaki, and T. Nagao
論文名 ''Real Time Measurement of Nitric Oxide Release from Cultured Endothelial Cells''
掲載誌頁 Biol. Pharm. Bull., 21, 1286-1289 (1998)
No.20
著　者 H. Kojima, N. Nakatsubo, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata, and T. Nagano
論文名 ''Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators''
掲載誌頁 Anal. Chem., 70, 2446-2453 (1998)
No.19
著　者 N. Nakatsubo, H. Kojima, K. Kikuchi, H. Nagoshi, Y. Hirata, D. Maeda, Y. Imai, T. Irimura, and T. Nagano
論文名 ''Direct Evidence of Nitric Oxide Production from Bovine Aortic Endothelial Cells Using New Fluorescence Indicators: Diaminofluoresceins''
掲載誌頁 FEBS Lett., 427, 263-266 (1998)
No.18
著　者 H. Kojima, N. Nakatsubo, K. Kikuchi, Y. Urano, T. Higuchi J. Tanaka, Y. Kudo, and T. Nagano
論文名 ''Direct Evidence of NO Production in Rat Hippocampus and Cortex Using a New Fluorescent Indicator: DAF-2 DA''
掲載誌頁 Neuroreport, 9, 3345-3348 (1998)
No.17
著　者 H. Kojima, K. Sakurai, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata, and T. Nagano
論文名 ''Development of a Fluorescent Indicator for Bioimaging of Nitric Oxide''
掲載誌頁 Chem. Pharm. Bull., 46, 373-375 (1998)
No.16
著　者 N. Nakatsubo, H. Kojima, K. Sakurai, K. Kikuchi, H. Nagoshi, Y. Hirata, T. Akaike, H. Maeda, Y. Urano, T. Higuchi, and T. Nagan
論文名 ''Improvement of Nitric Oxide Detection Method Using 2,3-Diaminonaphthalene and Its Application to Evaluation of Novel Nitric Oxide Synthase Inhibitor''
掲載誌頁 Biol. Phram. Bull., 21, 1247-1250 (1998)
No.15
著　者 Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, E. Suzuki, D. Nagata, K. Kimura, A. Goto, K. Kikuchi, T. Nagano, M. Hirobe, and M. Omata
論文名 ''Receptor Subtype for Vasopressin-induced Release of Nitric Oxide from Rat Kidney''
掲載誌頁 Hypertension, 29, 58-64 (1997)
No.14
著　者 H. Kojima, K. Kikuchi, M. Hirobe, and T. Nagano
論文名 ''Real-time Measurement of Nitric Oxide Production in Rat Brain by the Combination of Luminol-H2O2 Chemiluminescence and Microdialysis''
掲載誌頁 Neurosci. Lett., 233, 157-159 (1997)
No.13
著　者 H. Kojima, K. Sakurai, K. Kikuchi, S. Kawahara, Y. Kirino, H. Nagoshi, Y. Hirata, T. Akaike, H. Maeda, and T. Nagano
論文名 ''Development of a Fluorescent Indicator for the Bioimaging of Nitric Oxide''
掲載誌頁 Biol. Pharm. Bull., 20 1229-1232 (1997)
No.12
著　者 K. Kikuchi, S. N. Thorn, and D. Hilvert
論文名 ''Albumin-catalyzed Proton Transfer''
掲載誌頁 J. Am. Chem. Soc., 118, 8184-8185 (1996)
No.11
著　者 K. Kikuchi and D. Hilvert
論文名 ''Antibody Catalysis Via Strategic Use of Haptenic Charge''
掲載誌頁 Acta Chem. Scand., 50, 333-336 (1996)
No.10
著　者 K. Kikuchi, T. Nagano, and M. Hirobe
論文名 ''Nobel Detection Method of Nitric Oxide Using Horseradish Peroxidase''
掲載誌頁 Biol. Pharm. Bull., 19, 649-651 (1996)
No.9
著　者 Y. Hirata, H. Hayakawa, M. Kakoki, A. Tojo, K. Kimura, A. Goto, K. Kikuchi, T. Nagano,M. Hirobe, and M. Omata
論文名 ''Nitric Oxide Release from Kidneys of Hypertensive Rats Treated with Imidapril''
掲載誌頁 Hypertension, 27 Part 2, 672-678 (1996)
No.8
著　者 Y. Hirata, H. Hayakawa, E. Suzuki, K. Kimura, K. Kikuchi, T. Nagano, M. Hirobe, and M. Omata
論文名 “Direct Measurement of Endothelium Derived Nitric Oxide Release by Stimulation of Endothelin Receptors in Rat Kidney and Its Alteration in Salts-inducedHypertension”''
掲載誌頁 Circulation, 91, 1229-1235 (1995)
No.7
著　者 H. Hayakawa, Y. Hirata, E. Suzuki, M. Kakoki, K. Kikuchi, T. Nagano, M. Hirobe, and M. Omata
論文名 “Endothelium-derived Relaxing Factors in the Kidney of Spontaneously Hypertensive Rats''
掲載誌頁 Life Sci., 56, 401-408 (1995)
No.6
著　者 H. Hayakawa, Y. Hirata, E. Suzuki, K. Kimura, K. Kikuchi, T. Nagano, M. Hirobe, and M. Omata
論文名 “Long-term Administration of L-Arginine Improves Nitric Oxide Release from Kidney in DOCA Salt Hypertensive Rats''
掲載誌頁 Hypertension, 23, 752-756 (1994)
No.5
著　者 K. Kikuchi, T. Nagano, H. Hayakawa, Y. Hirata, and M. Hirobe
論文名 “Real Time Measurement of Nitric Oxide Produced Ex Vivo by Luminol-H2O2Chemiluminescence Method''
掲載誌頁 J. Biol. Chem., 268, 23106-23110 (1993)
No.4
著　者 K. Kikuchi, T. Nagano, H. Hayakawa, Y. Hirata, and M. Hirobe
論文名 “Detection of Nitric Oxide Production from a Perfused Organ by a Luminol-H2O2 Syste''
掲載誌頁 Anal. Chem., 65, 1794-1799 (1993)
No.3
著　者 H. Hayakawa, Y. Hirata, E. Suzuki, T. Sugimoto, H. Matsuoka, K. Kikuchi, T. Nagano, M. Hirobe, and T. Sugimoto
論文名 “Mechanisms for Altered Endothelium-dependent Vasodilation in Isolated Kidneys from SHR, DOCA-salt Hypertensive Rat and Dahl Salt-sensitive Rats''
掲載誌頁 Am. J. Physiol., 264, H1535-H1541 (1993)
No.2
著　者 K. Kikuchi, H. Hayakawa, T. Nagano, Y. Hirata, T. Sugimoto, and M. Hirobe
論文名 “New Method of Detecting Nitric Oxide Production''
掲載誌頁 Chem. Pharm. Bull., 40, 2233-2235 (1992)
No.1
著　者 K. Kikuchi, Y. Nagatsu, Y. Makino, T. Mashino, S. Ohta, and M. Hirobe
論文名 “Metabolism and Penetration through Blood-brain-barrier of Parkinsonism-related Compounds -1,2,3,4-Tetrahydroisoquinoline and1-Methyl-1,2,3,4-tetrahydroisoquinoline-''
掲載誌頁 Drug Met. Disp., 19, 257-262 (1991)